Analysis of allergen skin test results in 1 124 patients with allergic rhinitis in the junction of Guangdong and Guangxi provinces
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摘要: 目的:研究两广交界地区变应性鼻炎(AR)患者变应原致敏特征以及相关影响因素。方法:回顾1 124例AR患者的变应原皮肤点刺资料,统计各种变应原点刺阳性率并分析有关因素,包括患者年龄、点刺时间及性别对各种变应原点刺阳性率及对多重变应原阳性评分的影响。结果:吸入组变应原点刺阳性率最高的前3位为户尘螨(77.0%)、粉尘螨(77.1%)、蟑螂(42.3%);食入组阳性率最高的为海蟹(39.5%)、海虾(31.1%)、带鱼(10.8%),总体样本的多重变应原阳性评分为(3.6±2.7)分。各种变应原阳性率以及多重变应原阳性评分随着患者年龄、点刺时间的变化而变化,两者变化趋势相同。吸入组中户尘螨、粉尘螨与猫毛阳性率在男性组与女性组中存在显著差异。结论:螨类是该地区AR患者的主要致敏原,患者年龄、点刺时间以及性别对AR患者致敏原的检出率与多重致敏程度均有一定影响,多重变应原阳性评分可用来作为衡量患者致敏水平的指标之一。Abstract: Objective:To investigate the characteristics and influence factors of sensitization by allergens in patients with allergic rhinitis in the junction of Guangdong and Guangxi provinces.Method:One thousand one hundred and twenty-four patients who were diagnosed with allergic rhinitis by clinical history and symptoms underwent a skin prick test. The percent of allergens with positive skin response and Multiple Allergens Positive Scores were recorded, and their influence factors, included age, gender and test period were evaluated.Result:The percent of top three inhalant allergens with positive skin tests were as follow: dermatophagoides pteronyssinus(77.0%),dermatophagoides farina(77.1%),blattella germanica(42.3%);the percent of top three ingested allergens with positive skintests were as follow: crab(39.5%),shrimp(31.1%),ribbonfish(10.8%). The average Multiple Allergens Positive Score was(3.6±2.7). The percent of allergens with positive skin response and Multiple Allergens Positive Score of different allergens changed as age, gender and text period changed, and the changing trend of them was accordant. The percent inhalant allergens with positive skin tests in dermatophagoides pteronyssinus, dermatophagoides farinae and cat fur in different gender showed a significant difference.Conclusion:Acarine allergens were the most common allergens in patients with allergic rhinitis in the junction of Guangdong and Guangxi provinces. The percent of allergens with positive skin response and the severity of multiple allergy were influenced by age, gender and text period. The severity of multiple allergy can be measured by Multiple Allergens Positive Score.
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Key words:
- rhinitis /
- allergic /
- multiple allergens positive score /
- skin prick test
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[1] LEUNG R, HO P, LAM C W, et al.Sensitization to inhaled allergens as a risk factor for asthma and allergic diseases in Chinese population.[J].J Allergy Clin Immunol, 1997, 99:594-599.
[2] 滕丽珍, 郑宏智, 高燕萍, 等.佛山地区哮喘儿童过敏变应原状况的研究[J].热带医学杂志, 2006, 6 (1):89-90.
[3] 阮岩, 李笋, 杨占军, 等.广州地区变应性鼻炎患者常见变应原调查分析[J].实用中西医结合临床, 2006, 6 (3):46-47.
[4] 符征, 蔡飞, 孙亮, 等.海南省变应性鼻炎患者中变应原分布情况[J].中国耳鼻咽喉头颈外科, 2007, 14 (1):17-18.
[5] 陈育智, 马煜, 王红玉, 等.中国三城市儿童个人过敏原与喘息及气道高反应性的相关性研究[J].中华儿科杂志, 2003, 41 (7):538-541.
[6] 孟娟, 尹蓉, 张虹婷.成都地区变应性鼻炎患者皮肤点刺结果分析[J].华西医学, 2009, 24 (3):567-570.
[7] 余咏梅, 郭敏, 方润琪.云南地区10a的儿童变应性鼻炎变应原的临床分析[J].昆明医学院学报, 2009, 30 (5):111-113.
[8] 徐文飞, 刘恩梅, 周燕荣, 等.重庆地区1105例变应性疾病患儿吸入性变应原临床分析[J].实用儿科临床杂志, 2008, 23 (9):654-656.
[9] 陈建军, 孔维佳, 项济生, 等.湖北地区变应性鼻炎变应原年龄特征分析[J].临床耳鼻咽喉头颈外科杂志, 2008, 22 (15):683-685.
[10] 丁俊杰, 张建华, 许芳, 等.上海地区890例变应性鼻炎患者吸入变应原谱分析[J].临床耳鼻咽喉头颈外科杂志, 2012, 26 (4):164-166.
[11] 王成硕, 张罗, 韩德民, 等.北京地区变应性鼻炎患者吸入变应原谱分析[J].临床耳鼻咽喉科杂志, 2006, 20 (5):204-207.
[12] 柴若楠, 林小平, 谢华, 等.2001-2010年东北地区螨变应原诱发过敏性疾病调查[J].中华临床免疫和变态反应杂志, 2012, 6 (3):181-185.
[13] 王云丽, 赵祥, 李风荷, 等.内蒙古草原环境下鼻炎患者尘螨暴露与致敏的研究[J].中华耳鼻咽喉头颈外科杂志, 2012, 47 (1):19-25.
[14] 变应性鼻炎诊断和治疗指南[J].中国临床医生, 2010, 38 (6):67-68.
[15] BOUSQUET J, HEINZERLING L, BACHERT C, et al.Practical guide to skin prick tests in allergy to aeroallergens[J].Allergy, 2012, 67:18-24.
[16] LI J, SUN B, HUANG Y, et al.A multicentre study assessing the prevalence of sensitizations in patients with asthma and/or rhinitis in China[J].Allergy, 2009, 64:1083-1092.
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