肺表面活性蛋白D与IL-16在变应性鼻炎及鼻息肉中的表达和意义

孟令浩; 耿曼英; 闫保星; 卢星

doi:10.13201/j.issn.1001-1781.2013.05.012

肺表面活性蛋白D与IL-16在变应性鼻炎及鼻息肉中的表达和意义

- 郑州大学第二附属医院耳鼻咽喉科(郑州, 450014)

详细信息

通讯作者: 耿曼英,E-mail:manying66@126.com

中图分类号: R765.21;R765.25

收稿日期: 2012-07-17

Expression and significance of pulmonary surfactant protein D and IL-16 in allergic rhinitis and nasal polyps

- Department of Otolaryngology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, 450014, China

More Information

Corresponding author: GENG Manying, E-mail: manying66@126.com

Received Date: 17 July 2012

摘要

摘要: 目的: 检测肺表面活性蛋白D(SP-D)及IL-16在变应性鼻炎鼻黏膜组织和鼻息肉组织中的表达情况,探讨SP-D及IL-16在变应性鼻炎和鼻息肉发病中的作用及意义。方法: 采用免疫组织化学方法分别检测15例鼻中隔偏曲伴变应性鼻炎患者下鼻甲黏膜组织(变应性鼻炎组)、15例鼻息肉组织(鼻息肉组)和15例下鼻甲黏膜组织(对照组)中SP-D及IL-16表达。结果: SP-D、IL-16在3组中均有表达,但在变应性鼻炎组和鼻息肉组的表达均明显高于对照组(均P<0.01);SP-D和IL-16在变应性鼻炎组和鼻息肉组中的表达相比较差异无统计学意义(P>0.05)。结论: SP-D及IL-16在正常组织和病变组织中均有表达。SP-D可能参与了变应性鼻炎和鼻息肉的炎症反应过程。IL-16是变应性鼻炎和鼻息肉病变中重要的嗜酸粒细胞趋化因子,并增强了嗜酸粒细胞的局部作用,参与了变应性鼻炎和鼻息肉的病变过程。
- 肺表面活性蛋白D /
- 白介素16 /
- 鼻炎 /
- 变应性 /
- 鼻息肉
Abstract: Objective: To detect the expression and distribution of the lung surfactant protein D(surfactant protein D,SP-D ) and IL-16 in nasal mucosa of allergic rhinitis and nasal polyps,and then probe into their significance in the pathology of allergic rhinitis and nasal polyps.Method: Fifteen cases of allergic rhinitis,fifteen cases of nasal polyps and fifteen cases of inferior turbinate mucosa were studied to detect the expression of SP-D and IL-16 by immunohistochemistry method.Result: The expression of SP-D and IL-16 in allergic rhinitis and nasal polyps were dramatically higher in controls(P<0.01).There was no remarkable difference in the expression of SP-D and IL-16 between allergic rhinitis and nasal polyps(P＞0.05).Conclusion: Both normal tissue and diseased tissue express SP-D and IL-16.SP-D is likely to play key roles in the inflammatory reaction process of allergic rhinitis and nasal polyps.IL-16 is an important eosinophil chemokine in the process of allergic rhinitis and nasal polyps,and it can also enhance the local role of eosinophils,thus it can involve in the process of allergic rhinitis and nasal polyps disease.
- surfactant protein D /
- interleukin-16 /
- rhinitis /
- allergic /
- nasal polyps

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参考文献(9)

[1]	中华耳鼻咽喉头颈外科杂志编委会鼻科组,中华医学会耳鼻咽喉头颈外科学分会鼻科学组.变应性鼻炎诊断和治疗指南(2009年,武夷山)[J].中华耳鼻咽喉头颈外科杂志,2009,44(13):977-978.
[2]	王向东,韩德民,周兵,等.上下呼吸道炎症反应相关性研究[J].中华耳鼻咽喉科杂志,2003,8(4):247-250.
[3]	SCHAUB B,WESTLAKE R M,HE H,et al.Surfactantprotein D deficiency influences allergic immune respon-ses[J].Clin Exp Allergy,2004,34:1819-1826.
[4]	OOI E H,WORMALD P J,CARNEY A S,et al.Surfac-tant protein D expression in chronic rhinosinusitis pa-tients and immune responses in vitro to aspergillus andalternaria in a nasal explant model[J].Laryngoscope,2007,117:51-57.
[5]	NICOLL J,CRUIKSHANK W W,BRAZER W,et al.I-dentification of domains in IL-16 critical for biologicalactivity[J].J Immunol,1999,163:1827-1832.
[6]	陈建军,孔维佳,周月,等.IL-10,12,13,16在变应性鼻炎及血管运动性鼻炎患者血清中的表达[J].临床耳鼻咽喉头颈外科杂志,2007,21(20):913-915.
[7]	AKIYAMA K,KARAKI M,KOBAYSHI R,et al.IL-16variability and modulation by antiallergic drugs in a mu-rine experimental allergic rhinitis model[J].Int Arch Al-lergy Immunol,2009,149:315-322.
[8]	邓玉琴,左晶晶,陶泽璋,等.肺表面活性蛋白A在变应性鼻炎鼻黏膜及鼻息肉组织中的表达及意义[J].临床耳鼻咽喉头颈外科杂志,2009,23(14):642-645.
[9]	LIN K W,JEN K Y,SUAREZ C J,et al.Surfactant pro-tein D mediated decrease of allergen-induced inflamma-tion is dependent upon CTLA4[J].J Immunol,2010,184:6343-6349.