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摘要: 神经内分泌癌(NEC)是一种来源于神经内分泌细胞的恶性肿瘤，具有明确的临床、形态学和免疫组织化学特征，头颈部NEC在临床上很少见，喉是最常见的受累部位，舌根极为罕见。临床表现主要为进食疼痛、口腔内菜花样肿物、长久不愈合的溃疡性病变等。颌面部MRI和增强CT检查是此类疾病最常用的检查手段，可以发现肿瘤的占位性病变；病理光镜下胞质中发现神经内分泌颗粒可以诊断为NEC；但对于大多数病例，仅光镜下难以确诊，常需借助免疫组织化学染色等技术手段来确诊。本文报道1例舌根部NEC，介绍其病例特点和诊治经过，并对该病例进行相关文献复习。Abstract: Neuroendocrine carcinoma(NEC) is a malignant tumor derived from neuroendocrine cells, with distinct clinical, morphological and immunohistochemical characteristics. Neuroendocrine carcinoma of the head and neck is very rare in clinic. Larynx is the most common affected site, and the root of the tongue is extremely rare. The clinical manifestations are mainly eating pain, cauliflower like mass in the mouth, and ulcerative lesions that have not healed for a long time. Maxillofacial MRI and contrast-enhanced CT are the most commonly used examination tools for such diseases, which can detect the space-occupying lesions of tumors. Neuroendocrine granules found in the cytoplasm under pathological light microscope can be diagnosed as neuroendocrine carcinoma. However, for most cases, it is difficult to make a diagnosis only under light microscope, and it is often necessary to make a diagnosis by means of immunohistochemistry and other technical means. This paper reports a case of neuroendocrine carcinoma of the root of the tongue, introduces its characteristics, diagnosis and treatment, and reviews the relevant literature of this case.
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Key words:
- neuroendocrine carcinoma /
- tongue /
- head and neck region /
- case reoport
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