Less-than-subtotal parathyroidectomy in MEN1-ralated primary hyperparathyroidism: a case report
-
-
关键词:
- 多发性内分泌腺瘤病1型 /
- 甲状旁腺功能亢进 /
- 外科手术
Abstract: This case reported a case of multiple endocrine neoplasia type 1(MEN1). The patient was admitted to hospital on January 17 2020 due to persistent ostealgia and the elevated calcium level in the last 2 years. Laboratory tests showed elevated parathyroid hormone(PTH) and serum calcium level, which were 2295 ng/L(normal, 10-69 ng/L) and 3.15 mmol/L(normal, 2.03-2.54 mmol/L). Ultrasound of the neck found a solid nodule under the left inferior pole of thyroid, while 99mTc-MIBI SPECT/CT showed enhancement at the same place. Subsequently, cranial MRI found a tumor in sellar area, and abdominal MRI showed a tumor in left adrenal gland. Finally, the patient was diagnosed as MEN1. -
-
[1] Thakker RV, Newey PJ, Walls GV, et al. Clinical practice guidelines for multiple endocrine neoplasia type 1(MEN1)[J]. J Clin Endocrinol Metab, 2012, 97(9): 2990-3011. doi: 10.1210/jc.2012-1230
[2] Brandi ML, Gagel RF, Angeli A, et al. Guidelines for diagnosis and therapy of MEN type 1 and type 2[J]. J Clin Endocrinol Metab, 2001, 86(12): 5658-5671. doi: 10.1210/jcem.86.12.8070
[3] Lemos MC, Thakker RV. Multiple endocrine neoplasia type 1(MEN1): analysis of 1336 mutations reported in the first decade following identification of the gene[J]. Hum Mutat, 2008, 29(1): 22-32. doi: 10.1002/humu.20605
[4] Rizzoli R, Green J 3rd, Marx SJ. Primary hyperparathyroidism in familial multiple endocrine neoplasia type I. Long-term follow-up of serum calcium levels after parathyroidectomy[J]. Am J Med, 1985, 78(3): 467-474. doi: 10.1016/0002-9343(85)90340-7
[5] Gopinath P, Mihai R. Hyperparathyroidism[J]. Surgery(Oxford), 2011, 29(9): 451-458.
[6] Doherty GM. Multiple endocrine neoplasia type 1[J]. J Surg Oncol, 2005, 89(3): 143-150. doi: 10.1002/jso.20181
[7] Nastos C, Papaconstantinou D, Kofopoulos-Lymperis E, et al. Optimal extent of initial parathyroid resection in patients with multiple endocrine neoplasia syndrome type 1: A meta-analysis[J]. Surgery, 2021, 169(2): 302-310. doi: 10.1016/j.surg.2020.08.021
[8] Kartini D, Dasawala F, Ham MF. Less than subtotal parathyroidectomy in multiple endocrine neoplasia type 1: A case report and review of the literature[J]. Int J Surg Case Rep, 2020, 77: 337-340. doi: 10.1016/j.ijscr.2020.10.140
[9] Montenegro F, Brescia M, Lourenço DM Jr, et al. Could the Less-Than Subtotal Parathyroidectomy Be an Option for Treating Young Patients With Multiple Endocrine Neoplasia Type 1-Related Hyperparathyroidism?[J]. Front Endocrinol(Lausanne), 2019, 10: 123. doi: 10.3389/fendo.2019.00123
[10] Bergenfelz A, Nordenström E, Almquist M. Morbidity in patients with permanent hypoparathyroidism after total thyroidectomy[J]. Surgery, 2020, 167(1): 124-128. doi: 10.1016/j.surg.2019.06.056
[11] Almquist M, Ivarsson K, Nordenström E, et al. Mortality in patients with permanent hypoparathyroidism after total thyroidectomy[J]. Br J Surg, 2018, 105(10): 1313-1318. doi: 10.1002/bjs.10843
[12] Versnick M, Popadich A, Sidhu S, et al. Minimally invasive parathyroidectomy provides a conservative surgical option for multiple endocrine neoplasia type 1-primary hyperparathyroidism[J]. Surgery, 2013, 154(1): 101-105. doi: 10.1016/j.surg.2013.03.004
[13] Kluijfhout WP, Beninato T, Drake FT, et al. Unilateral Clearance for Primary Hyperparathyroidism in Selected Patients with Multiple Endocrine Neoplasia Type 1[J]. World J Surg, 2016, 40(12): 2964-2969. doi: 10.1007/s00268-016-3624-9
[14] Choi HR, Choi SH, Choi SM, et al. Benefit of diverse surgical approach on short-term outcomes of MEN1-related hyperparathyroidism[J]. Sci Rep, 2020, 10(1): 10634. doi: 10.1038/s41598-020-67424-5
-
下载:
图(6)
计量
- 文章访问数: 1344
- PDF下载数: 523
- 施引文献: 0