脑源性微粒在头颈部肿瘤放射性脑损伤中对小胶质细胞极化作用的研究进展

杜家虞; 唐洁; 张倩; 马晓洁

doi:10.13201/j.issn.2096-7993.2021.01.023

脑源性微粒在头颈部肿瘤放射性脑损伤中对小胶质细胞极化作用的研究进展

- 川北医学院(四川南充，637000)

详细信息

通讯作者: 马晓洁，E-mail：maxiaojie8@sina.com

中图分类号: R739.91

收稿日期: 2019-12-19

刊出日期: 2021-01-05

Research progress of brain-derived microparticles on microglia polarization in radiation-induced brain injury of head and neck tumors

More Information

Corresponding author: MA Xiaojie, E-mail: maxiaojie8@sina.com

Received Date: 19 December 2019

Publish Date: 05 January 2021

摘要

- 头颈部肿瘤 /
- 放射性脑损伤 /
- 小胶质细胞极化 /
- 脑源性微粒
Abstract: Radiation brain injury(RBI) is one of the complications of radiotherapy for head and neck malignant tumors, which has a serious impact on the prognosis and quality of life of patients. The existence of radiation-induced brain injury not only limits the radiation therapy dose of head and neck malignant tumors, but also restricts the efficacy of tumor patients, and has a serious impact on the prognosis and quality of life of patients. The pathogenesis of radiation-induced brain injury is not yet completely clear, we use various clinical treatment for radiation brain injury patients to alleviate some clinical symptoms, but it cannot effectively reverse the brain injury process. In recent years, with the further exploration of radiation-induced brain injury and the accumulation of clinical experience, studies have found that microglial polarization plays an important role in radiation-induced brain injury, and brain-derived particles can activate microglia. This article reviews the research progress of brain-derived microparticles on the polarization of microglia in radiation-induced brain injury of head and neck tumors.
- head and neck neoplasms /
- radiation-induced brain injury /
- microglia polarization /
- brain-derived particles

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