Analysis of the association between helicobacter pylori infection and laryngeal lesions
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摘要: 目的 探讨幽门螺旋杆菌感染与喉病损的相关性。方法 选取204例喉病损患者为喉病损组，选择同期无喉病损且愿意接受电子纤维胃镜检查的150例健康体检者为对照组。观察2组幽门螺旋杆菌阳性率，并分析喉病损患者幽门螺旋杆菌感染与临床特征的关系。结果 喉病损组和对照组幽门螺旋杆菌阳性率分别为56.86%和47.33%，差异无统计学意义(χ2=3.150，P=0.076)；喉病损患者中，≥60岁与 < 60岁、男性与女性、有胃疾病史与无胃疾病史患者的幽门螺旋杆菌阳性率差异均无统计学意义；喉病损患者中喉良性病变、喉癌前病变、喉恶性病变组幽门螺旋杆菌阳性率分别为53.70%、55.56%和75.00%，喉恶性病变幽门螺旋杆菌阳性率的差异有统计学意义(χ2=6.338，P=0.012)；在喉癌前病变、喉恶性病变组，伴幽门螺旋杆菌感染的胃肠道病变明显高于不伴幽门螺旋杆菌感染者(P < 0.05)。结论 幽门螺旋杆菌与喉病损的严重程度相关，与喉恶性病变具有高度相关性，这为喉恶性肿瘤的治疗提供了理论依据。Abstract: Objective To investigate the relationship between Helicobacter pylori(H.pylori) infection and laryngeal lesions.Method 204 patients with laryngeal lesions were arranged into laryngeal lesions group, and 150 healthy persons who were willing to accept the electronic fiber gastroscopy examination in the same period were selected as control group. The positive rate of H.pylori infection in the two groups was observed and the association between H.pylori infection status and clinical characteristics in patients with laryngeal diseases was analyzed.Result The positive rate of H.pylori infection in laryngeal lesion group and control group were 56.86% and 47.33%(χ2=3.150, P=0.076), respectively. Among the patients with laryngeal lesion, the positive detection rate of H.pylori was not associated with age, gender, or gastric disease history. The positive rate of H.pylori infection in benign lesions, precancerous lesions and laryngeal malignant lesions were 53.70%, 55.56% and 75.00%, respectively. The difference of positive rate of H.pylori infection in laryngeal malignant lesions was significantly higher than other kinds of lesions(χ2=6.338, P=0.012). Among laryngeal precancerous lesions and laryngeal malignant lesions patients, the appearance rate of gastrointestinal lesions were significantly higher in the patients with positive H.pylori infection than those without H.pylori infection(P < 0.05).Conclusion H.pylori infection was positively related to the severity of laryngeal lesions and highly positively related to laryngeal malignant lesions.
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Key words:
- helicobacter pylori /
- infection /
- laryngeal neoplasms
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表 1 喉病损患者幽门螺旋杆菌感染与临床特征的关系
例(%) 临床特征 阳性 阴性 χ2 P 年龄/岁 0.002 0.967 < 60 92(56.79) 70(43.21) ≥60 24(57.14) 18(42.86) 性别 0.259 0.611 男 88(57.89) 64(42.11) 女 28(53.85) 24(46.15) 胃疾病史 0.001 0.971 有 34(56.67) 26(43.33) 无 82(56.94) 62(43.06) 喉病损分类 喉良性病变 58(53.70) 50(46.30) 1.019 0.313 喉癌前病变 40(55.56) 32(44.44) 1.316 0.251 喉恶性病变 18(75.00) 6(25.00) 6.338 0.012 
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表 2 胃食管病变与喉病损的关系
例(%) 喉良性病变 喉癌前病变 喉恶性病变 有 无 有 无 有 无 HP(+) 22(37.93) 36(62.07) 30(75.00) 10(25.00) 14(77.78) 4(22.22) HP(-) 25(50.00) 25(50.00) 10(31.25) 22(68.75) 1(16.67) 5(83.33) χ2 0.182 0.521 0.623 P 0.207 0.021 0.015
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