Clinical observation of the anti-reflux treatment for the chronic pharyngitis patients with the reflux finding score from 8 to 10
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摘要: 目的 观察临床诊断慢性咽炎且伴反流体征评分量表(RFS)低阳性评分(8~10分)患者抗反流的疗效。方法 选取临床诊断为慢性咽炎且RFS评分为8~10分的患者112例，随机分为治疗组和对照组。治疗组予以质子泵抑制剂+胃肠促动力药抗反流治疗及清咽利喉中成药，对照组予以单纯清咽利喉中成药，比较两组治疗有效率及各组治疗前后的症状体征评分变化。结果 治疗组总有效率(77.36%)高于对照组(30.61%)，差异有统计学意义(P<0.01)。治疗组治疗前后各症状VAS评分差异有统计学意义(P<0.01)。结论 临床诊断慢性咽炎且伴有RFS阳性低评分患者，予以中成药治疗同时加用抗反流药物可明显改善症状。Abstract: Objective To evaluate the anti-reflux treatment efficacy for the chronic pharyngitis patients with the reflux finding score(RFS) from 8-10.Method One hundred and twelve patients with clinical diagnosis of chronic pharyngitis and RFS score of 8-10 were randomly divided into control and treatment groups. The treantment group was given the proton pump inhibitors, gastrointestinal motility drugs and the traditional Chinese patent drugs(treatment group). The control group was given only the traditional Chinese patent drugs(control group).Result The visual analogue scale(VAS) of the patients in treatment group declined significantly after treatment. The efficacy of treatment group was significantly higher than that of control group(77.36% vs 30.61%, P<0.01).Conclusion For the patients with chronic pharyngitis with RFS 8-10, anti-reflux treatment should be used together with traditional Chinese patent drugs.
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Key words:
- pharyngitis /
- reflux symptomindex /
- reflux finding score /
- visual analogue scale
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表 1 治疗组和对照组的指标比较
分 组别 治疗前 治疗后 RSI RFS VAS RSI RFS VAS 咽异物感 持续清嗓 咽异物感 持续清嗓 治疗组 8.89±2.60 9.02±1.00 7.79±1.86 7.04±1.07 4.74±2.101) 8.91±0.77 2.36±1.241) 2.74±1.131) 对照组 9.12±2.49 9.10±0.71 8.20±1.29 6.61±2.23 8.47±2.36 8.76±1.01 7.84±1.36 6.73±1.56 t -0.467 -0.483 -1.305 1.214 -8.455 0.842 -21.271 -14.881 P 0.642 0.630 0.195 0.229 <0.001 0.402 <0.001 <0.001 与治疗前比较，1)P<0.05。 
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表 2 治疗组和对照组的疗效比较
例(%) 组别 例数 显效 有效 无效 总有效 治疗组 53 21(39.62)1) 20(37.74)1) 12(22.64)1) 41(77.36)1) 对照组 49 12(24.49) 3(6.12) 34(69.39) 15(30.61) 与对照组比较，1)P<0.01。
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