OSA与肠道微生态平衡研究相关进展

陈前程; 王红阳; 张盼盼; 付爱双; 戈艳蕾; 朱晓颖; 张倩; 张雪; 余华丽

doi:10.13201/j.issn.1001-1781.2019.11.026

OSA与肠道微生态平衡研究相关进展

- 华北理工大学附属医院呼吸内科(河北唐山, 063000)
基金项目:
河北省卫生与计划生育委员会重点科技研究计划课题(No:20150081)

河北省高等学校科学技术研究项目课题(No:QN2016198)

河北省自然科学基金资助项目(No:H2014209231)

详细信息

通讯作者: 王红阳,E-mail:tsmywhy2010@163.com

中图分类号: R563.8

收稿日期: 2018-11-13

Progress in studies on obstructive sleep apnea and intestinal microecological balance

More Information

Corresponding author: , E-mail: tsmywhy2010@163.com

Received Date: 13 November 2018

摘要

摘要: OSA是以睡眠时反复出现的打鼾、呼吸暂停导致低氧灌注间断反复发作,并以白天嗜睡、神志精神异常等为主要表现的睡眠呼吸障碍性疾病。由于OSA引起的反复间歇性低氧、二氧化碳潴留所致高碳酸血症以及睡眠结构的失调,可引起机体生理功能的紊乱,进而引发的一系列并发症。目前有研究报道指出,OSA与多种疾病的发生发展具有极为密切的关系。肠道是人体最重要的营养物质消化和吸收器官。人类肠道中寄生的微生物达上千种,统称为肠道微生物组。经历了长期而漫长的进化
- 睡眠呼吸暂停综合征 /
- 阻塞性 /
- 肠道微生态 /
- 肠道黏膜损伤 /
- 氧化应激反应 /
- 代谢综合征 /
- 胰岛素抵抗
Abstract: Obstructive sleep apnea(OSA) is closely related to the development of various diseases. Hypoxic perfusion caused by OSA can mediate the occurrence of inflammatory reactions or aggravate metabolic disorders to affect intestinal microecological balance. Intestinal bacteria can participate in the development of inflammatory reaction or metabolic disorder by itself or its components, and the oxidative stress reaction of the body develops in a vicious circle. The mechanism has not yet been fully elucidated, so we reviewed the research progress on OSA and intestinal microecological balance.
- sleep apnea /
- obstructive /
- intestinal microecology /
- intestinal mucosal injury /
- oxidative stress response /
- metabolic syndrome /
- insulin resistance

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