Research progress in the application of intralymphatic allergen immunotherapy in allergic diseases
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摘要: 过敏性疾病是指由IgE介导的Ⅰ型变态反应性疾病,主要包括变应性鼻炎（allergic rhinitis,AR）、过敏性哮喘、特应性皮炎以及食物过敏等。AR是发生在鼻黏膜的Ⅰ型变态反应性疾病,其主要治疗方法包括药物治疗和免疫治疗,其中特异性免疫治疗作为AR的一线治疗方法被各国指南推荐使用[1-4]。目前常用的特异性免疫治疗方法主要包括皮下免疫疗法（subcutaneous immunotherapy,SCIT）和舌下免疫疗法(sublinAbstract: Although subcutaneous immunotherapy(SCIT) and sublingual immunotherapy(SLIT) have a positive effect, there are drawbacks such as long treatment time period, frequent treatment times, and risk of adverse reactions. Peripheral superficial lymph node injection of allergen immunotherapy(ILIT) as an emerging specific immunotherapy method has the advantages of high safety, less adverse reactions, short treatment time, less treatment times, less patient pain, and exact curative effect. In recent years, more and more scholars have conducted extensive research on intra-lymphatic injection of immunotherapy for allergic diseases. This paper systematically summarizes the theoretical basis, method, safety, effectiveness and possible immune mechanism of ILIT
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Key words:
- specific immunotherapy /
- lymph node injection /
- allergic disease
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