OSA患者肾素（原）受体水平与性别及疾病严重程度的相关性

吴金鹏; 陈爱民; 骆献阳; 刘建捷

doi:10.13201/j.issn.1001-1781.2019.07.011

OSA患者肾素（原）受体水平与性别及疾病严重程度的相关性

- 1 厦门大学附属第一医院耳鼻咽喉头颈外科(福建厦门, 361003);
- 2 秦皇岛市第一医院口腔科

详细信息

通讯作者: 吴金鹏,E-mail:601948902@qq.com

中图分类号: R563.8

收稿日期: 2019-03-19

Correlation between（Pro）renin receptor levels and gender and disease severity in patients with obstructive sleep apnea syndrome

- 1 Department of Otorhinolaryngology Head and Neck Surgery, the First Affiliated Hospital of Xiamen University, Xiamen, 361003, China;
- 2 Department of Stomatology, the First Hospital of Qinhuangdao

More Information

Corresponding author: WU Jin-peng, E-mail: 601948902@qq.com

Received Date: 19 March 2019

摘要

摘要: 目的:探讨OSA患者肾素(原)受体[(P)RR]水平与患者性别和疾病严重程度的相关性。方法:2010-03-2018-03期间选择接受治疗并确诊的80例OSA患者(OSA组)为研究对象,另外选择20例健康体检者作为对照组,考察健康人、不同性别和疾病严重程度OSA患者的血浆可溶性肾素(原)受体[s(P)RR]水平及临床参数的变化。结果:OSA组的血浆s(P)RR浓度显著高于对照组。在所有患者中,血浆s(P)RR浓度均随着疾病程度的升高而升高,在男性和女性之间均表现出相同的变化趋势。此外,血浆s(P)RR浓度与所有患者的腰臀比、血红蛋白A1c(HbA1c)、AHI和氧减饱和度指数呈显著正相关,而与肾小球滤过率(eGFR)、平均血氧饱和度(MSpO₂)₂和最低血氧饱和度(minSpO₂)呈显著负相关(P<0.05)。女性受试者中,血浆s(P)RR浓度与腰臀比和AHI呈显著正相关,而与eGFR呈显著负相关(P<0.05)。男性受试者中,血浆s(P)RR浓度与腰臀比、HbA1c、肾素水平、AHI和氧减饱和度指数呈显著正相关,而与eGFR、MSpO₂和minSpO₂呈显著负相关(P<0.05)。应用经鼻持续气道正压通气呼吸机治疗后患者的血浆s(P)RR浓度均显著降低。另外,Epworth嗜睡量表评分、AHI、MSpO₂、minSpO₂和氧减饱和度指数均得到显著改善(P<0.05)。结论:OSA患者的血浆s(P)RR水平与患者的疾病严重程度呈显著正相关,可直接反映患者的疾病严重程度。此外,患者的腰臀比和HbA1c过高、eGFR过低均可影响血浆s(P)RR水平,并有可能导致OSA病情加重。
- 睡眠呼吸暂停 /
- 阻塞性 /
- 肾素(原)受体 /
- 性别
Abstract: Objective: The aim of this study is to investigate the relationship between the level of (pro) renin(P)RR in obstructive sleep apnea syndrome (OSA) patients, and the gender and disease severity of the disease.Method: From March 2010 to March 2018, eighty OSA patients who were treated and diagnosed in our hospital were selected as subjects. Another 20 healthy subjects were selected as the control group. Plasma soluble (pro) renin receptor [s(P)RR] levels and clinical parameters were measured in healthy subjects and OSA patients with different sex and disease severity. Result: The plasma s(P)RR concentrations were significantly higher in OSA patients than that in control group. In all patients, plasma s(P)RR concentrations increased with increasing disease levels and showed the same trend between men and women. In addition, in all patients, plasma s(P)RR concentrations were significantly positively correlated with waist-to-hip ratio, HbA1c, AHI, and oxygen desaturation index. There was a significant negative correlation between saturation (MSpO₂) and minimum oxygen saturation (minSpO₂) (P<0.05). In female subjects, plasma s(P)RR concentrations were significantly positively correlated with waist-to-hip ratio and AHI, but significantly negatively correlated with eGFR (P<0.05). In male subjects, plasma s(P)RR concentration was significantly positively correlated with waist-to-hip ratio, HbA1c, renin level, AHI and oxygen desaturation index, but negatively correlated with eGFR, MSpO₂ and minSpO₂ (P<0.05). Plasma s(P)RR concentrations were significantly reduced after treatment with nasal continuous positive airway pressure ventilator. In addition, ESS, AHI, MSpO₂, minSpO₂, and oxygen desaturation index were all significantly improved (P<0.05).Conclusion: Plasma s(P)RR levels in OSA patients are significantly positively correlated with the severity of the disease and can directly reflect the severity of the disease. In addition, the patient with higher waist-to-hip ratio and HbA1c, and lower eGFR can effect plasma s (P)RR levels, and may lead to OSA aggravation.
- sleep apnea /
- obstructive /
- (pro) renin receptor /
- gender

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参考文献(16)

[1]	NGUYEN G.Renin, (pro) renin and receptor:an update.[J].Clin Sci, 2011, 120:169-172.
[2]	TAKAHASHI K, OHBA K, KANEKO K.Ubiquitous expression and multiple functions of biologically active peptides[J].Peptides, 2015, 72:184-191.
[3]	MIZUGUCHI Y, MORIMOTO S, KIMURA S, et al.Prediction of response to medical therapy by serum soluble (pro) renin receptor levels in Graves'disease[J].PLoS One, 2018, 13:e0195464.
[4]	QUADRI S, SIRAGY H M. (Pro) renin receptor contributes to regulation of renal epithelial sodium channel.[J].Journal of Hypertension, 2016, 34:1927-1937.
[5]	NISHIJIMA T, TAJIMA K, TAKAHASHI K, et al.Elevated plasma levels of soluble (pro) renin receptor in patients with obstructive sleep apnea syndrome:association with polysomnographic parameters[J].Peptides, 2014, 56:14-21.
[6]	中华医学会呼吸病学分会睡眠呼吸障碍学组.阻塞性睡眠呼吸暂停低通气综合征诊治指南 (2011年修订版)[J].中华结核和呼吸杂志, 2012, 35 (3):162-165.
[7]	彭莉莉, 李进让, 孙建军.Epworth嗜睡量表简体中文版信度和效度评价[J].中华耳鼻咽喉头颈外科杂志, 2011, 46 (1):44-49.
[8]	简化MDRD公式预测慢性肾病患者肾小球滤过率的应用评价及校正[J].中国实用内科杂志, 2006, 26 (9):665-669.
[9]	李飞燕, 况九龙.阻塞性睡眠呼吸暂停低通气综合征的异质性及临床分型研究进展[J].山东医药, 2016, 56 (2):98-101.
[10]	张静, 陈宝元, 韩晋英, 等.阻塞性睡眠呼吸暂停综合征合并原发性高血压肾素-血管紧张素-醛固酮系统的变化研究[J].中国实用内科杂志, 2011, 31 (8):626-628.
[11]	祖力米热·阿布力孜, 孙晓靖, 陈玉岚, 等.肾素、醛固酮协同作用对原发性高血压病合并阻塞性睡眠呼吸暂停低通气综合征患者左心结构和功能的影响研究[J].中国全科医学, 2017, 20 (7):817-822.
[12]	TANI Y, YAMADA S, INOSHITA N, et al.Regulation of growth hormone secretion by (pro) renin receptor[J].Sci Rep, 2015, 5:10878-10880.
[13]	ALMENDROS I, FARRÉ, RAMON, PLANAS A M, et al.Tissue Oxygenation in Brain, Muscle, and Fat in a Rat Model of Sleep Apnea:Differential Effect of Obstructive Apneas and Intermittent Hypoxia[J].Sleep, 2011, 34:1127-1133.
[14]	肖雪娜, 王莹, 王心捷.糖尿病患者糖化血红蛋白与血清CA199水平的相关性研究[J].中国糖尿病杂志, 2014, 22 (10):928-930.
[15]	吕颖, 刘熹, 张春燕, 等.短期持续正压通气对阻塞性睡眠呼吸暂停低通气综合征合并慢性肾脏疾病患者的影响[J].同济大学学报 (医学版), 2017, 38 (2):65-68.
[16]	鲁颖, 田卢峰, 韩锐, 等.nCPAP治疗对合并中重度OSAHS的2型糖尿病患者胰岛素抵抗及瘦素水平的影响[J].中国卫生检验杂志, 2011, 21 (11):2665-2667.