丁苯酞对重度老年OSAHS患者血浆一氧化氮和内皮素-1的影响

张盼盼; 汪彦辉; 孟庆玲; 韩晓庆; 戈艳蕾; 王玲; 刘晨; 王袁; 黄超; 王红阳

doi:10.13201/j.issn.1001-1781.2019.03.014

丁苯酞对重度老年OSAHS患者血浆一氧化氮和内皮素-1的影响

- 1. 华北理工大学附属医院呼吸科(河北唐山, 063000);
- 2. 华北理工大学临床医学院;
- 3. 迁西县人民医院
基金项目:
河北省卫生与计划生育委员会重点科技研究计划课题 (No:20150081)

河北省高等学校科学技术研究项目课题 (No:QN2016198)

河北省自然科学基金资助项目 (No:H2014209231)

详细信息

通讯作者: 王红阳,E-mail:tsmywhy@163.com.

中图分类号: R563.8

收稿日期: 2018-09-19

Effects of butylphthalide on plasma nitric oxide and endothelin-1 in severe elderly OSAHS patients

- 1. Department of Respiration, North China University of Science and Technology Affiliated Hospital, Tangshan, 063000, China;
- 2. Clinical Medicine College of North China University of Science and Technology;
- 3. People's Hospitsal of Qianxi

More Information

Corresponding author: WANG Hongyang, E-mail: tsmywhy@163.com

Received Date: 19 September 2018

摘要

摘要: 目的:探讨丁苯酞对重度老年OSAHS患者血浆一氧化氮(NO)和内皮素-1(ET-1)的影响及临床意义。方法:将120例经PSG确诊的重度老年OSAHS患者随机分为无创呼吸机对照组、丁苯酞治疗组和丁苯酞联合无创呼吸机组,每组40例。无创呼吸机对照组患者行双水平气道正压通气治疗6个月,丁苯酞治疗组患者口服丁苯酞治疗6个月,丁苯酞联合无创呼吸机组患者在行双水平气道正压通气治疗的同时,口服丁苯酞治疗6个月,分别于治疗前及治疗3、6个月后采用免疫酶联吸附法检测血浆NO、ET-1水平的变化,并进行对比分析。结果:3组患者治疗前血浆NO和ET-1比较差异无统计学意义(P>0.05);与治疗前比较,3组患者治疗3、6个月后血浆NO水平升高,ET-1水平下降(P<0.01);与丁苯酞治疗组治疗后比较,无创呼吸机对照组及丁苯酞联合无创呼吸机组患者治疗3、6个月后血浆NO水平升高,ET-1水平下降,差异有统计学意义(P<0.05);与无创呼吸机对照组比较,丁苯酞联合无创呼吸机组患者治疗3、6个月后血浆NO水平升高,ET-1水平下降,差异有统计学意义(P<0.05)。结论:丁苯酞可通过升高血浆NO、降低血浆ET-1的水平改善重度老年OSAHS患者的血管内皮功能。
- 睡眠呼吸暂停低通气综合征 /
- 阻塞性 /
- 老年人 /
- 一氧化氮 /
- 内皮素-1
Abstract: Objective:To investigate the effect of butylphthalide on plasma nitric oxide (NO) and endothelin-1 (ET-1) in severe elderly OSAHS patients.Method:A total of 120 severe elderly OSAHS patients were chosen by PSG measurement.According to random number table method, OSAHS patients were randomly divided into noninvasive ventilation control group (n=40), butylphthalide treatment group (n=40) and butylphthalide combined with non-invasive ventilation group (n=40).Non-invasive ventilation control group was given double level airway positive pressure ventilation treatment for six months, butylphthalide treatment group accepted oral butylphthalide therapy for six months, butylphthalide combined with non-invasive ventilation group was given double level airway positive pressure ventilation treatment and accepted oral butylphthalide therapy for six months.The changes of plasma NO and ET-1 were detected by immunoenzyme adsorption before treatment and three and six months after treatment.Result:The difference of plasma NO and ET-1 before treatment in the three groups was not statistically significant (P>0.05).Compared with before treatment, the level of plasma NO decreased and the level of plasma ET-1 increased in the three groups after three and six months treatment (P <0.01).Compared with butylphthalide treatment group, the level of plasma NO increased and the level of plasma ET-1 decreased after 3 and 6 months of treatment in both non-invasive ventilation control group and butylphthalide combined with non-invasive ventilation group (P<0.05).Compared with non-invasive ventilation control group, the level of plasma NO increased and the level of plasma ET-1 decreased after 3 and 6 months of treatment in butylphthalide combined with non-invasive ventilation group (P<0.05).Conclusion:Butylphthalide may improve the vascular endothelial function of severe elderly OSAHS patients by increasing the level of NO and decreasing the level of ET-1 in plasma.
- sleep apnea hypopnea syndrome /
- obstructive /
- elderly patients /
- nitric oxide /
- endothelin-1

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