始发于头颈部Castleman病的诊疗分析

刘丽; 王凌芳; 桑建中; 陈磊

doi:10.13201/j.issn.1001-1781.2018.11.015

始发于头颈部Castleman病的诊疗分析

- 1. 河南医学高等专科学校医学系(郑州, 451191);
- 2. 郑州大学第一附属医院耳鼻咽喉头颈外科
基金项目:
河南省科技攻关项目（No：172102310059）

详细信息

通讯作者: 刘丽,E-mail:linlinma2013@sina.com

中图分类号: R653

收稿日期: 2018-02-23

Analysis of the diagnosis and treatment of Castleman disease originating in the head and neck

- 1. Department of Medicine, Henan Medical College, Zhengzhou, 451191, China;
- 2. Department of Otolaryngology Head and Neck Surgery, the First Affiliated Hospital of Zhengzhou University

More Information

Corresponding author: LIU Li, E-mail: linlinma2013@sina.com

Received Date: 23 February 2018

摘要

摘要: 目的：提高对始发于头颈部的Castleman病（CD）的诊断和治疗水平。方法：15例始发于头颈部的CD患者，发生于右侧颈部者8例，左侧6例，双侧1例；11例为局灶型CD（UCD），4例为多中心型CD（MCD）。所有患者均接受影像学检查，并于全身麻醉下行颈部肿物切除术，4例MCD患者均在术后行药物治疗。结果：随访12~69个月，1例患者因肿块与腮腺关系密切，术后出现轻度面瘫；1例术后瘢痕生长明显，偶有瘙痒；1例肩部轻度疼痛；4例多中心患者带瘤生存；2例分别于随访57个月、65个月后失访，随访期间未见复发；余6例未见异常。结论：CD患者临床表现各异，病理检查为其诊断的重要依据，明确诊断后仍需完善相关检查，避免漏诊。UCD患者一般预后较好，MCD患者预后往往欠佳。对于咽旁间隙肿块并发甲状腺肿瘤患者，可同期手术。
- 头颈部 /
- Castleman病 /
- 诊断 /
- 治疗
Abstract: Objective: To improve diagnosis and treatment of castleman's disease (CD) originating in the head and neck. Method: Of 15 cases of Castleman's disease originating in the head and neck, 8 cases occurred in the right side of the neck, 6 cases in the left side, and 1 case in both sides. Eleven cases were focal type CD (UCD), and 4 cases were multi-center type CD (MCD). All patients underwent imaging examination and neck nephrectomy. Four patients with MCD received drug treatment after surgery. Result: During follow-up from 12 to 69 months, one patient suffered a slight facial paralysis due to a close relationship between mass and the parotid gland. One patient had obvious postoperative scar growth and occasional itching; another patient suffered mild pain in shoulder; 4 cases of multi-center patients survived with tumor; 2 cases lost follow-up at 57 months, 65 months after follow-up, respectively. There were no recurrence in these two cases during the follow-up period; the remaining 6 cases had no exceptions. Conclusion: The clinical manifestations of CD patients are different. Pathological examination is an important basis for diagnosis. After a definite diagnosis, related examinations need to be completed. The LCD patients generally had a good prognosis, and the MCD patients often had a poor prognosis. For patients with parapharyngeal masses complicated by thyroid tumors, surgery can be performed at the same time.
- head and neck /
- Castleman disease /
- diagnosis /
- treatment

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