观察防风固本颗粒对变应性鼻炎肺郁脾虚患者外周血单个核细胞培养上清中IL-4、IL-5、IL-10、IFN-γ细胞因子水平的影响

马瑞霞; 侯丽; 虎峻瑞

doi:10.13201/j.issn.1001-1781.2017.21.010

观察防风固本颗粒对变应性鼻炎肺郁脾虚患者外周血单个核细胞培养上清中IL-4、IL-5、IL-10、IFN-γ细胞因子水平的影响

- 1 宁夏医科大学总医院耳鼻咽喉科(银川, 750004);
- 2 银川市第三人民医院耳鼻咽喉科
基金项目:
宁夏自然科学基金 (No:N215231)

详细信息

通讯作者: 马瑞霞, E-mail:Maruixia4368@sina.com

中图分类号: R765.21

收稿日期: 2017-09-17

To observe the effect of "Fangfenggubenkeli" on IL-4,IL-5,IL-10 and IFN-γcytokines in PBMC supernatant of allergic rhinitis patients with lung depression and spleen efficiency

- 1 Department of Otorhinolaryngology, the General Hospital of Ningxia Medical University, Yinchuan, 750004, China;
- 2 Department of Otorhinolaryngology, the Third People's Hospital of Yinchuan

More Information

Corresponding author: MA Ruixia, E-mail: Maruixia4368@sina.com

Received Date: 17 September 2017

摘要

摘要: 目的: 观察防风固本颗粒对变应性鼻炎肺郁脾虚患者PBMC培养上清中IL-4、IL-5、IL-10、IFN-γ细胞因子水平的影响。方法: 将100例患者按照自愿原则分为2个组。其中治疗组50例,予以古方防风固本颗粒;对照组50例,给予盐酸左西替利嗪。均口服4周为1个疗程,治疗前和治疗满4周后分别测定2组患者的IL-4、IL-5、IL-10、IFN-γ情况,比较2组患者治疗前后实验室指标的变化。结果: 经4周治疗后,2组患者IL-4含量明显比用药前下降,与用药前值相比, 差异有统计学意义(P<0.01);IL-5、IL-10的含量均在治疗前后无明显变化(均P>0.05);IFN-γ含量明显比用药前上升(P<0.01)。治疗后2组间鼻痒、喷嚏、流涕比较差异有统计学意义(圴P<0.01),防风固本汤疗效明显。结论: 防风固本颗粒对变应性鼻炎肺郁脾虚患者的作用机制可能在于升高血清IFN-γ水平,降低血清IL-4水平,改善细胞因子水平,从而从整体改善Th1/Th2失衡状态。
- 防风固本颗粒 /
- 鼻炎 /
- 变应性 /
- 肺郁 /
- 脾虚 /
- 细胞因子
Abstract: Objective: To observe the effect of "Fangfenggubenkeli" on IL-4, IL-5, IL-10 and IFN-γ cytokines in PBMC supernatant of allergic rhinitis' patients with lung depression and spleen deficiency.Method: One hundred patients were randomly divided into two groups. The treatment group of 50 cases, was given to ancient side of the "Fangfenggubenkeli". The control group of 50 patients, was given to cetirizine hydrochloride, oral treatment. The levels of IL-4, IL-5, IL-10 and IFN-γ in the two groups were measured before and after treatment of 1 month. The changes of the laboratory indexes were compared between the two groups before and after treatment.Result: The levels of IL-4 in the two groups were significantly lower than those before treatment (P<0.01), and the levels of IFN-γ were significantly higher than those before treatment (P<0.01), there was a statistically significant difference.Conclusion: The mechanism of "Fangfenggubenkeli" in patients with allergic rhinitis with lung depression may be related to the IFN-γ level, lower IL-4 level. Thereby Fangfenggubenkeli would improved the Th1/Th2 imbalance state as a whole.
- Fangfenggubenkeli /
- rhinitis /
- allergic /
- lung depression /
- spleen deficiency /
- cytokines

HTML全文

参考文献(12)

[1]	韩德民.变应性鼻炎[M].北京:人民卫生出版社, 2007:5-5.
[2]	RHEE C S.Current specific immunotherapy for allergic rhinitis:perspectives from otorhinolaryngologists[J].Allergy Asthma Immunol Res, 2014, 6:273-275.
[3]	张迎宏, 朱丽, 王琳, 等.变应性鼻炎鼻部及鼻外症状学分析[J].临床耳鼻咽喉头颈外科杂志, 2014, 24 (2):133-135.
[4]	李阳阳, 赵明, 文连姬, 等.白细胞介素-5和白细胞介素-16在变应性鼻炎患者血清中的表达及临床意义[J].中国耳鼻咽喉头颈外科, 2015, 22 (3):135-137.
[5]	中华医学会耳鼻咽喉头颈外科学分会鼻科学组.变应性鼻炎诊断和治疗指南 (2015年, 天津)[J].中华耳鼻咽喉头颈外科杂志, 2016, 51 (1):6-24.
[6]	国家中医药管理局批准发布.中医病证诊断疗效标准[M].北京:中国医药科技出版社, 2012:101-108.
[7]	李丹青, 常惠玉, 骆寒冰.布地奈德联用沙丁胺醇雾化吸入结合内服中药汤剂治疗过敏性鼻炎疗效观察[J].中华中医药学刊, 2012, 21 (12):2798-2801.
[8]	祁雪萍, 索利敏, 赵长青, 等.T细胞免疫球蛋白黏蛋白分子4参与变应性鼻炎发病机制的实验研究[J].中华耳鼻咽喉头颈外科杂志, 2014, 49 (4):283-287.
[9]	陈玉卿, 穆会君, 张桢, 等.孟鲁司特钠辅助治疗老年变应性鼻炎的疗效及对IL-6、IL-8、IL-10的影响[J].中国老年学杂志, 2016, 36 (13):3263-3265.
[10]	史军, 刘玉, 严士海, 等.益气温阳方对变应性鼻炎Treg细胞调控的研究[J].中华中医药杂志, 2014, 29 (6):2037-2039.
[11]	徐友文, 李婉红, 张亚琼, 等.布地奈德对支气管哮喘儿童血CKLF-1、IL-4和IFN-γ水平的影响[J].中华全科医学, 2015, 13 (6):992-995.
[12]	张卫华, 刘舟, 王俊壹, 等.桂枝汤对AR大鼠鼻黏膜上皮细胞AQP5表达及cAMP/PKA-CREB信号通路的影响[J].中华中医药杂志, 2016, 5 (1):283-287.