IgG4相关疾病的嗅觉障碍

顾东升; 李佩忠; 陈志亮; 徐彧; 王成禹; 孙晓阳

doi:10.13201/j.issn.1001-1781.2017.21.009

IgG4相关疾病的嗅觉障碍

- 1 南京医科大学附属淮安第一医院耳鼻咽喉头颈外科(江苏淮安, 223000);
- 2 南京医科大学附属淮安第一医院神经外科

详细信息

通讯作者: 孙晓阳, E-mail:sunxiaoyang2012@yahoo.com.cn

中图分类号: R765.6

收稿日期: 2017-07-03

The clinical study of olfactory dysfunction in IgG4-related disease

- 1 Department of Otorhinolaryngology Head and Neck Surgery, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, 223000, China;
- 2 Department of Neurosurgery, Huai'an First People's Hospital, Nanjing Medical University

More Information

Corresponding author: SUN Xiaoyang, E-mail: sunxiaoyang2012@yahoo.com.cn

Received Date: 03 July 2017

摘要

摘要: 目的: 评估IgG4相关疾病患者的嗅觉功能。方法: 对22例IgG4相关疾病患者通过嗅棒测试来衡量其嗅觉功能,并分析患者临床特点,包括血清IgG4含量和受累脏器数目,鼻腔鼻窦CT扫描及应用改良Lund-Mackay评分系统来探讨嗅觉障碍的病因。结果: 22例患者中有11例(50%)存在嗅觉障碍,嗅觉障碍组与嗅觉正常组的临床特征之间差异无统计学意义。结论: IgG4相关性疾病患者的嗅觉障碍与IgG4阳性细胞数目、受累器官数目之间无相关性,并且嗅觉障碍与鼻腔鼻窦CT得分之间也无相关性。IgG4相关疾病患者嗅觉障碍发病率高,但该嗅觉障碍是可逆的。嗅觉障碍似乎是IgG4相关疾病新发现的重要表现。
- IgG4 /
- 嗅棒 /
- 嗅觉障碍
Abstract: Objective: IgG4-related disease is a newly recognized systemic disease, and its elucidation is progressing. However, little is known about its sinonasal manifestations.The aim of this study was to assess the olfaction of patients with IgG4-related disease.Method: Twenty-two patients with IgG4-related disease underwent the odor stick identification test to measure olfactory function.We analyzed the clinical features, including serum IgG4 levels, involved organs, and sinonasal computed tomography scores to explore the etiology of olfactory dysfunction.Result: Eleven patients with IgG4-related disease were found to have olfactory dysfunction. There were no differences in the clinical features between the olfactory dysfunction group and the normal group.Conclusion: There were no correlation between olfactory function and serum IgG4 level, involved organs or sinonasal computed tomography scores.We found that the prevalence of olfactory dysfunction was high in patients with IgG4-related disease and that it could be reversed.Olfactory dysfunction appears to be a novel important manifestation of IgG4-related disease.
- IgG4-related disease /
- the odor stick identification test /
- olfactory function

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