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Abstract: Interleukin 35 (IL-35), a new IL-12 family cytokine, is consisting of IL-12P35 and Epstein-Barr virus-induced gene 3 (EBI3) and is required by regulatory T cells (Tregs) for maximal activity.IL-35 is regarded as apromising new type of anti-inflammatory treatment factor, by the in-vitro and mouse models studies confirmed, although the studies have not been able to elucidate the role of IL-35 in human respiratory allergic disease.This paper describes the IL-35 and respiratory allergic diseases of bronchial asthma, allergic rhinitis and research progress in nasal polyps.
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Key words:
- IL-35 /
- IL-12family cytokine /
- asthma /
- rhinitis /
- allergic /
- nasal polyps /
- immunotherapy
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[1] DEVERGNE O, BIRKENBACH M, KIEFF E.Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12form a novel heterodimeric hematopoietin[J].Proc Natl Acad Sci U S A, 1997, 94:12041-12046.
[2] COLLISON L W, WORKMAN C J, KUO T T, et al.The inhibitory cytokine IL-35contributes to regulatory T-cell function[J].Nature, 2007, 450:566-569.
[3] NAKANO S, MORIMOTO S, SUZUKI S, et al.Immunoregulatory role of IL-35in T cells of patients with rheumatoid arthritis[J].Rheumatology (Oxford), 2015, 54:1498-1506.
[4] WU S, LI Y, LI Y, et al.Interleukin-35attenuates collagen-induced arthritis through suppression of vascular endothelial growth factor and its receptors[J].Int Immunopharmacol, 2016, 34:71-77.
[5] CAI Z, WONG C K, KAM N W, et al.Aberrant expression of regulatory cytokine IL-35in patients with systemiclupus erythematosus[J].Lupus, 2015, 24:1257-1266.
[6] LI X, TIAN L, DONG Y, et al.IL-35inhibits HBVantigen-specific IFN-γ-producing CTLs in vitro[J].Clin Sci (Lond), 2015, 129:395-404.
[7] BAJORIUNIENE I, MALAKAUSKAS K, LAVIN-SKIENE S, et al.Response of peripheral blood Th17 cells to inhaled Dermatophagoides pteronyssinus in patientswith allergic rhinitis and asthma[J].Lung, 2012, 190:487-495.
[8] 万俊, 罗英, 杨春萍, 等.变应性鼻炎患者外周学IL-35及EBI3 mRNA和IL-12A mRNA表达的研究[J].临床耳鼻咽喉头颈外科杂志, 2014, 28 (13):952-954.
[9] COLLISON L W, WORKMAN C J, KUO T T, et al.The inhibitory cytokine IL-35contributes to regulatory T-cell function[J].Nature, 2007, 450:566-569.
[10] COLLISON L W, VIGNALI D A.Interleukin-35:odd one out or part of the family[J]?Immunol Rev, 2008, 226:248-262.
[11] CHOI J, LEUNG P S, BOWLUS C, et al.IL-35and Autoimmunity:a Comprehensive Perspective[J].Clin Rev Allergy Immunol, 2015, 49:327-332.
[12] VIGNALI D A, KUCHROO V K.IL-12family cytokines:immunological playmakers[J].Nat Immunol, 2012, 13:722-728.
[13] ZOU W.Regulatory T cells, tumour immunity and immunotherapy[J].Nat Rev Immunol, 2006, 6:295-307.
[14] COLLISON L W, CHATURVEDI V, HENDER-SON A L, et al.IL-35-mediated induction of a potent regulatory T cell population[J].Nat Immunol, 2010, 11:1093-1101.
[15] KOCHETKOVA I, GOLDEN S, HOLDERNESSK, et al.IL-35stimulation of CD39+ regulatory Tcells confers protection against collagen II-inducedarthritis via the production of IL-10[J].J Immunol, 2010, 184:7144-7153.
[16] NIEDBALA W, WEI X Q, CAI B, et al.IL-35is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells[J].Eur JImmunol, 2007, 37:3021-3029.
[17] WHITEHEAD G S, WILSON R H, NAKANO K, et al.IL-35 production by inducible costimulator (ICOS) -positive regulatory T cells reversesestablished IL-17-dependent allergic airways disease[J].JAllergy Clin Immunol, 2012, 129:207-215.
[18] MA Y, LIU X, WEI Z, et al.The expression of a novel anti-inflammatory cytokine IL-35and its possible significance inchildhood asthma[J].Immunol Lett, 2014, 162 (1 Pt A):11-17.
[19] WONG C K, LEUNG T F, CHU I M, et al.Aberrant expression of regulatory cytokine IL-35and pattern recognition receptor NOD2 inpatients with allergic asthma[J].Inflammation, 2015, 38:348-360.
[20] WANG W, LI P, CHEN Y F, et al.A potential immunopathogenic role for reduced IL-35expression in allergic asthma[J].J Asthma, 2015, 52:763-771.
[21] 扶红根, 雷后兴.白介素-35与支气管哮喘的相关性研究进展[J].中国免疫学杂志, 2016, 32 (1):123-126.
[22] HUANG X, CHEN Y, ZHANG F, et al.Peripheral Th17/Treg cell-mediated immunity imbalance in allergic rhinitis patients[J].Braz J Otorhinolaryngol, 2014, 80:152-155.
[23] TAO B, RUAN G, WANG D, et al.Imbalance of Peripheral Th17 and Regulatory T Cells in Children with Allergic Rhinitis and Bronchial Asthma[J].Iran J Allergy Asthma Immunol, 2015, 14:273-279.
[24] SHEN H, WANG C, FAN E, et al.Upregulation of interleukin-35subunits in regulatory T cells in a murine model of allergic rhinitis[J].ORL J Otorhinolaryngol Relat Spec, 2014, 76:237-247.
[25] 尹雪, 任秀敏, 刘春苗, 等.变应性鼻炎患者IL-35对于Treg/Th17细胞平衡的调控作用[J].临床耳鼻咽喉头颈外科杂志, 2016, 30 (3):213-216.
[26] SHEN Y, TANG X Y, YANG Y C, et al.Impaired balance of Th17/Treg in patients with nasal polyposis[J].Scand J Immunol, 2011, 74:176-185.
[27] SHEN Y, HU G H, YANG Y C, et al.Allergen induced Th17 response in the peripheral blood mononuclear cells (PBMCs) of patientswith nasal polyposis[J].Int Immunopharmacol, 2012, 12:235-240.
[28] SHEN Y, HU G H, KANG H Y, et al.Allergen induced Treg response in the peripheral blood mononuclear cells (PBMCs) of patients with nasal polyposis[J].Asian Pac J Allergy Immunol, 2014, 32:300-307.
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