鼻腔鼻窦滑膜肉瘤的发病机制及研究进展

周政; 苗刚勇; 李云秋

doi:10.13201/j.issn.1001-1781.2017.07.022

鼻腔鼻窦滑膜肉瘤的发病机制及研究进展

- 湖南省人民医院头颈外科(长沙, 410005)
基金项目:
湖南省科学技术厅科技计划项目 (No:2013FJ6034)

详细信息

通讯作者: 李云秋, E-mail:entliyunqiu@126.com

中图分类号: R739.6

收稿日期: 2016-12-19

Pathogenesis and research progress of the synovial sarcoma of the nasal cavity and sinus

More Information

Corresponding author: LI Yunqiu, E-mail: entliyunqiu@126.com

Received Date: 19 December 2016

摘要

- 鼻腔 /
- 鼻窦 /
- 滑膜肉瘤 /
- 发病机制 /
- 发展
Abstract: Synovial sarcoma of the nasal cavity and sinus are rare, comprise less than 0.1% of all soft tissue malignancies.Synovial sarcoma is a malignant mesenchymal tumor with variable epithelial differentiation, which is defined by the presence of a specific chromosomal translocation that generates SS18-SSX fusion oncogenes.The treatment include surgery, radiotherapy, chemotherapy.As the delicate anatomy of the nasal cavity and sinus limits the ability to obtain wide surgical margins.This maybe the reason why there is a higher local recurrence rate and worse disease-specific survival in head and neck sarcomas compared to other sites.
- nasal cavity /
- sinuses /
- synovial sarcoma /
- pathogenesis /
- development

HTML全文

参考文献(26)

[1]	贾志峰, 郑丽华, 赵亚恒, 等.滑膜肉瘤相关发病机制的研究进展[J].肿瘤防治研究, 2015, 42 (7):716-719.
[2]	VILLAROEL-SALINAS J, CAMPOS-MARTINEZJ, ORTIZ-HIDALGO C.Synovial sarcoma of the tongue confirmed by molecular detection of the SYT-SSX2 fusion gene transcript[J].Int J Surg Pathol, 2012, 20:386-389.
[3]	LIN H C, FRIEDMAN M, KUO F Y, et al.Synovial sarcoma of the Eustachian tube[J].Head Neck, 2009, 31:1245-1248.
[4]	THWAY K, FISHER C.Synovial sarcoma:defining features and diagnostic evolution[J].Ann Diagn Pathol, 2014, 18:369-380.
[5]	CAI W, SUN Y, WANG W, et al.The effect of SYT-SSX and extracellular signal-regulated kinase (ERK) on cell proliferation in synovial sarcoma[J].Pathol Oncol Res, 2011, 17:357-367.
[6]	CARMODY SONI E E, SCHLOTTMAN S, ERKI-ZAN H V, et al.Loss of SS18-SSX1 inhibits viability and induces apoptosis in synovial sarcoma[J].Clin Orthop Relat Res, 2014, 472:874-882.
[7]	BARHAM W, FRUMP A L, SHERRILL T P, et al.Targeting the Wnt pathway in synovial sarcoma models[J].Cancer Discov, 2013, 3:1286-1301.
[8]	BARCO R, GARCIA C B, EID J E.The synovial sarcoma-associated SYT-SSX2 oncogene antagonizes the polycomb complex protein Bmi1[J].PLoS One, 2009, 4:e5060.
[9]	BASILE L E, HOCH B, DILLON J K.Synovial Sarcoma of the Tongue:Report of a Case[J].J Oral Maxillofac Surg, 2016, 74:95-103.
[10]	NIELSEN T O, POULIN N M, LADANYI M.Synovial sarcoma:recent discoveries as a roadmap to new avenues for therapy[J].Cancer Discov, 2015, 5:124-134.
[11]	ZHANG X M, ZHOU C, GU H, et al.Correlation of RKIP, STAT3 and cyclin D1 expression in pathogenesis of gastric cancer[J].Int J Clin Exp Pathol, 2014, 7:5902-5908.
[12]	ISHIKI H, MIYAJIMA C, NAKAO K, et al.Synovial sarcoma of the head and neck:rare case of cervical metastasis[J].Head Neck, 2009, 31:131-135.
[13]	JONES B C, SUNDARAM M, KRANSDORF M J.Synovial sarcoma:MR imaging findings in 34patients[J].AJR Am J Roentgenol, 1993, 161:827-830.
[14]	DE ALMEIDA-LAWALL M, MOSQUEDA-TAY-LOR A, BOLOGNA-MOLINA R E, et al.Synovial sarcoma of the tongue:case report and review of the literature[J].J Oral Maxillofac Surg, 2009, 67:914-920.
[15]	MOHAMMADI G, KHANSARINIA A.Synovial Sarcoma-A Rare Tumor of the Larynx[J].Iran JOtorhinolaryngol, 2016, 28:233-236.
[16]	KOMIS C, LAGOGIANNIS G A, FARATZIS G, et al.Synovial sarcoma of the tongue:report of a case and review of the literature[J].J Oral Maxillofac Surg, 2008, 66:154-160.
[17]	FRANCHI A, PALOMBA A, CARDESA A.Current diagnostic strategies for undifferentiated tumours of the nasal cavities and paranasal sinuses[J].Histopathology, 2011, 59:1034-1045.
[18]	QASSID O, ALI A, THWAY K.Synovial Sarcoma With Myoid Differentiation[J].Int J Surg Pathol, 2016, 24:525-527.
[19]	梁海英, 张银华, 房新志.TLE1在滑膜肉瘤中的表达研究[J].新疆医学, 2013, 43 (9):62-64.
[20]	李彤, 马春跃.头颈部滑膜肉瘤诊治研究进展[J].中国实用口腔科杂志, 2012, 5 (12):728-732.
[21]	ACOSTA DíAZ H, TRINIDAD RUIZ G, REJAS E, et al.[Synovial sarcoma of the nasal cavity.A case report] [J].Acta Otorrinolaringol Esp, 2011, 62:246-248.
[22]	赵雪松, 张杰武, 贾金良, 等.头颈部滑膜肉瘤的治疗及预后分析[J].中国肿瘤临床, 2007, 34 (20):1175-1180.
[23]	HARB W J, LUNA M A, PATEL S R, et al.Survival in patients with synovial sarcoma of the head and neck:association with tumor location, size, and extension[J].Head Neck, 2007, 29:731-740.
[24]	COINDRE J M.Grading of soft tissue sarcomas:review and update[J].Arch Pathol Lab Med, 2006, 130:1448-1453.
[25]	BACCARI EZZINE S, CHELBI E, BOUZAIDI K.Intracardiac metastasis of primary synovial sarcoma of the lung[J].Asian Cardiovasc Thorac Ann, 2013, 21:623-623.
[26]	BAROSA J, RIBEIRO J, AFONSO L, et al.Head and neck sarcoma:analysis of 29cases[J].Eur Ann Otorhinolaryngol Head Neck Dis, 2014, 131:83-86.