Expression of serum interleukin 5 and osteopontin in patients with allergic rhinitis
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摘要: 目的:探讨变应性鼻炎(AR)患者血清IL-5和骨桥蛋白(OPN)检测的临床价值。方法:采用ELISA法检测62例初诊AR患者和49名健康对照个体血清IL-5和OPN水平,分析AR患者血清IL-5、OPN与患者临床特征的关系。结果:AR患者血清IL-5和OPN水平较健康个体明显增高。合并哮喘的AR患者IL-5和OPN水平较未合并哮喘者明显增高。AR患者血清OPN与症状总评分(TNSS)和血清IgE均呈正相关,但与嗜酸粒细胞计数无关;IL-5与TNSS、血清IgE和嗜酸粒细胞计数均呈正相关。OPN与IL-5呈正相关。结论:OPN和IL-5参与了AR的发病机制,可以作为AR的病情评价标志物。Abstract: Objective:To investigate the role of serum IL-5 and osteopontin(OPN) in patients with allergic rhinitis(AR).Method:The levels of serum IL-5 and OPN in 62 treatment-naive AR patients were determined using ELISA. The relationships among the expression of serum IL-5, OPN and clinical characteristics were analyzed.Result:Serum OPN and IL-5 in AR patients were significantly higher than those of healthy individuals. Patients with asthma had significantly higher OPN and IL-5 than that of patients without asthma.OPN in AR patients was positively correlated with TNSS and total IgE, but not blood eosinophil count. IL-5 was positively correlated with TNSS, total IgE and blood eosinophil count. OPN is positively correlated with IL-5.Conclusion:Both OPN and IL-5 are involved in the pathogenesis of AR. Serum OPN and IL-5 can be useful biomarkers for evaluating the severity of AR.
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Key words:
- rhinitis /
- allergic /
- osteopontin /
- interleukin-5 /
- Th2 response
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