Expression and clinical pathological implications of carbonic anhydrase 9 and P glycoprotein in laryngeal squamous cell carcinoma
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摘要: 目的:研究喉鳞状细胞癌与喉良性病变组织中碳酸酐酶9(CA Ⅸ)和P糖蛋白(P-gp)表达的差异,分析2种蛋白在喉鳞状细胞癌组织中表达的相关性,及两者与喉鳞状细胞癌临床病理特征的关系。方法:采用免疫组织化学EnVision二步法分别检测47例喉鳞状细胞癌组织、20例声带息肉组织中CA Ⅸ和P-gp的表达情况。结果:CA Ⅸ和P-gp在喉鳞状细胞癌组织中的阳性表达率和它们在声带息肉中的表达均差异有统计学意义(P<0.05),且两者在喉鳞状细胞癌组织中的表达呈正相关(r=0.324,P<0.05)。CA Ⅸ蛋白表达与喉鳞状细胞癌的临床分期、淋巴结转移有关(P<0.05);与喉鳞状细胞癌组织学分级、原发部位无关(P>0.05)。P-gp表达与喉鳞状细胞癌的临床分期、组织学分级有关(P<0.05);与喉鳞状细胞癌的原发部位、淋巴结转移无关(P>0.05)。结论:CA Ⅸ与P-gp的高表达可能在喉鳞状细胞癌的病情进展中起一定作用。Abstract: Objective:To identify the difference of CA Ⅸ and P-gp expression level between laryngeal squamous cell carcinoma (LSCC) and benign tissues, evaluate the relationship of these two proteins in LSCC, and their correlation with clinical and pathological features.Method:Immunohistochemical detection of CA Ⅸ and P-gp were performed in 47 cases of LSCC and 20 cases of vocal cord polyps.Result:Overexpression of CA Ⅸ and P-gp both in LSCC and in vocal cord polyp (P<0.05) were confirmed, with a correlation between the two proteins in LSCC (r=0.324, P<0.05). The expression of CA Ⅸ was related to clinical staging and lymph node metastasis in LSCC (P<0.05). While P-gp was related to clinical staging and histological grading in LSCC (P<0.05).Conclusion:The overexpression of CA Ⅸ and P-gp may play a role in LSCC progression.
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Key words:
- laryngeal neoplasm /
- carbonic anhydraseⅨ /
- P glycoprotein /
- immunohistochemistry
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[1] PEREZ-GUTIERREZ S,GONZALEZ-CAMPORA R,AMERIGO-NAVARRO J,et al.Expression of Pglycoprotein and metallothionein in gastrointestinal stromaltumor and leiomyosarcomas.Clinical implications[J].Pathol Oncol Res,2007,13:203-208.
[2] XIE J,LI D W,CHEN X W,et al.Expression and significance of hypoxia-inducible factor-1αand MDR1/P-glycoprotein in laryngeal carcinoma tissue and hypoxic Hep-2cells[J].Oncol Lett,2013,6:232-238.
[3] 李大伟,高尚,陈歆维,等.缺氧诱导因子-1α与P糖蛋白在LSCC中的表达及临床意义[J].山东大学耳鼻喉眼学报,2010,24(1):6-9.
[4] SASSO E,VITALE M,MONTELEONE F,et al.Bindingof carbonic anhydraseⅨto 45S rDNA genes is prevented by exportin-1in hypoxic cells[J].Biomed Res Int,2015,2015:674-692.
[5] ILARDI G,ZAMBRANO N,MEROLLA F,et al.Histopathological determinants of tumor resistance:aspecial look to the immunohistochemical expression of carbonic anhydraseⅨinhuman cancers[J].Curr Med Chem,2014,21:1569-1582.
[6] BUANNE P,RENZONE G,MONTELEONE F,et al.Characterization of carbonicanhydraseⅨinteractome reveals proteins assisting its nuclear localization inhypoxic cells[J].J Proteome Res,2013,12:282-292.
[7] BROCKTON N,DORT J,LAU H,et al.High stromal carbonic anhydraseⅨexpression is associated with decreased survival in P16-negative head-and-neck tumors[J].Int J Radiat Oncol Biol Phys,2011,80:249-257.
[8] LI L,JIANG A C,DONG P,et al.The characteristics of Hep-2cell withmultiple drug resistance induced by Taxol[J].Otolaryngol Head Neck Surg,2007,137:659-664.
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