数据挖掘在喉癌临床研究中的应用

徐雯; 张睿; 鄂琪敏; 刘加林; 梁传余

doi:10.13201/j.issn.1001-1781.2015.14.011

数据挖掘在喉癌临床研究中的应用

- 1 四川大学华西医院华西临床医学院医学信息学教研室(成都, 610041);
- 2 四川大学华西医院信息中心;
- 3 四川大学华西医院耳鼻咽喉头颈外科
基金项目:
国家自然科学基金面上项目(No:71273182)

四川省科技支撑计划项目资助(No:2011FZ0035)

详细信息

通讯作者: 刘加林,E-mail:dljl8@163.com

中图分类号: R739.65

收稿日期: 2015-01-30

The clinical application of data mining in laryngeal cancer

- 1 Department of Medical Informatics, West China School of Medicine, Sichuan University, Chengdu, 610041, China;
- 2 Information Center, West China Hospital, Sichuan University;
- 3 Department of Otolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University

More Information

Corresponding author: LIU Jialin, E-mail: dljl8@163.com

Received Date: 30 January 2015

摘要

摘要: 目的:通过喉癌临床数据的挖掘与分析,为喉癌的早期预测诊断提供决策判断依据。方法:在后关系型Caché数据库上建立喉癌数据仓库,结合IBM Cognos进行联机在线分析,实现喉癌数据多维呈现,并构建喉癌科研数据集于Weka环境中实现特征选择及数据挖掘。结果:构建喉癌数据仓库;实现喉癌数据多维呈现;通过数据挖掘提取喉癌的集成式和二段式特征子集,发现与喉癌高度相关的潜在特征。结论:运用数据挖掘技术对发现喉癌潜在临床知识、辅助临床诊断具有重要的价值。
- laryngeal cancer /
- data mining /
- data analysis
Abstract: Objective: To provide a basis for the prediction and early diagnosis of laryngeal cancer through data mining and analysis.Method: We constructed a laryngeal cancer data warehouse on Caché and combined IBM Cognos for on-line analytical processing. After building research data set, software Weka was used for feature selection and data mining.Result: Data warehouse of laryngeal cancer was structured and Laryngeal cancer data were multidimensional presented. It is possible to find the high relevant and potential characteristics associated with laryngeal cancer by integration and 2-phase feature subset of data mining to extract the larynx.Conclusion: Application of data mining technology could help clinicians to find potential clinical knowledge and make early diagnosis of laryngeal cancer.
- laryngeal cancer /
- data mining /
- data analysis

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参考文献(11)

[1]	王晓舟, 王钦. S100A4和上皮性钙黏素在喉鳞状细胞癌中的表达及意义[J]. 临床耳鼻咽喉头颈外科杂志, 2010, 24(21):993-995.
[2]	马玥莹, 刘良发, 黄德亮, 等. 晚期喉癌患者术后生存回顾性分析[J]. 临床耳鼻咽喉头颈外科杂志, 2013, 27(15):844-846.
[3]	NAM S, PARK T. Pathway-based evaluation in early onset colorectal cancer suggests focal adhesion and immunosuppression along with Epithelial-Mesenchymal transition[J]. PloS One, 2012, 7:1-14.
[4]	AHMED K, ABDULLAH-AL-EMRAN, JESMIN T, et al. Early detection of lung cancer risk using data mining[J]. Asian Pacifc J Cancer Prev, 2013, 14:595-598.
[5]	鄂琪敏, 刘加林, 黎勇, 等. 基于Web的一体化喉癌临床数据库的构建及应用[J]. 临床耳鼻咽喉头颈外科杂志, 2014, 28(15):1181-1184.
[6]	TING S, SHUM C, KWOK S, et al. Data Mining in Biomedicine:Current Applications and Further Directions for Research[J]. J Software Engineering Appl, 2009, 2:150-159.
[7]	RENAUDO A, L'HOSTE S, GUIZOUARN H, et al. Cancer cell cycle modulated by a functional coupling between sigma-1 receptors and Cl-channels[J]. J Biological Chem, 2007, 282:2259-2267.
[8]	杨胜萍, 张青云. 七种恶性肿瘤血清离子检测水平分析[J]. 中国现代医学杂志, 2014, 24(1):9-12.
[9]	YU W F, ZHAO Y L, WANG K, et al. Inhibition of cell proliferation and arrest of cell cycle progression by blocking chloride channels in human laryngeal cancer cell line Hep-2[J]. Neoplasma, 2009, 56:224-229.
[10]	YAMASHITA H, KITAYAMA J, TAGURI M, et al. Effect of preoperative hyperfibrinogenemia on recurrence of colorectal cancer without a systemic inflammatory response[J]. World J Surg, 2009, 33:1298-1305.
[11]	李大伟, 董频.喉鳞癌患者凝血功能与肿瘤复发的关系[J]. 现代肿瘤医学, 2010, 18(9):1721-1722.