Clinical features,levels of protein carbonyl in serum of obstrucitive sleep apnea syndrome with type 2 diabetes mellitus
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摘要: 目的:观察2型糖尿病中阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的患病情况,临床特点及血清蛋白羰基水平。方法:选择2型糖尿病患者203例,进行多导联睡眠呼吸监测,记录AHI、年龄、身高、体重指数(BMI)、腰围、糖尿病病程,测定空腹血糖、糖化血红蛋白(HbA1c)、血清蛋白羰基(PCO)水平。结果:2型糖尿病患者中OSAHS患病率为79.2%,其中重度30.4%,中度45.4%,轻度24.2%。伴OSAHS患者的BMI、腰围、空腹血糖、HbA1c及血清PCO水平均高于未合并OSAHS者,差别有统计学意义(P<0.01)。回归分析发现HbA1c与OSAHS患病风险呈独立正相关(P<0.05,OR=6.11),HbA1c、BMI、腰围、病程、血清PCO水平均与AHI独立正相关,HbA1c为最主要的独立危险因素(P<0.05)。结论:2型糖尿病患者中OSAHS的患病率较高,合并OSAHS的患者血糖控制差,体内蛋白质氧化损伤加重。Abstract: Objective: To explore the prevalence, clinical feature and levels of protein carbonyl(PCO) in serum of type 2 diabetes mellitus combining obstrucitive sleep apnea syndrome(OSAHS).Method: Two hundred and three patients with type 2 diabetes were taken multi lead sleep detection and their AHI,age, height,body mass index(BMI),waistline,duration of diabetes,fast blood glucose,HbA1c level and level of PCO in serum were recorded.Result: The prevalence of OSAHS was 79.2% in 203 patients, serious apnea 30.4%, moderate apnea 45.4%, mild apnea 24.2%. BMI, waistline, fast blood glucose,HbA1c level and level of PCO in serum were higher in patients complicated with OSAHS(P<0.01). HbA1c was independently and positively correlated with patients with OSAHS risk(P<0.05,OR 6.11). The independent correlation factors of AHI included HbA1c level,BMI, waistline,duration of diabetes and level of PCO in serum,with HbA1c as the predominant factor(P<0.05).Conclusion: The prevalence of OSAHS was higher in patients of type 2 diabetes mellitus combining (OSAHS). Moreover, in these patients poor glucose control and aggravated protein oxidative injury were observed.
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Key words:
- type 2 diabetes /
- obstructive sleep apnea syndrome /
- prevalence /
- HbA1c /
- protein carbonyl
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