Assessment of the curative effective of cochlear implantation in childer with GJB2-associated NSSNHL
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摘要: 目的：评价携带GJB2基因突变的儿童人工耳蜗植入后的疗效。方法：对40例携带GJB2基因突变的人工耳蜗植入患儿进行疗效评估，测试内容包括：声场助听听阈测试、（婴幼儿）有意义听觉整合量表、听觉行为分级标准评分、言语可懂度分级标准评分及普通话早期言语感知测试。以80例未检出已知热点突变者为对照组。结果：携带GJB2基因突变的患儿术后声场助听听阈优于对照组，其余测试与对照组比较差异无统计学意义（P>0.05）。结论：携带GJB2基因突变的非综合征性感音神经性聋患儿适于行人工耳蜗植入手术，术后效果满意。Abstract: Objective: To analyze the curative effect of CI in children with GJB2-associated NSSNHL.Method: The evaluations of curative effect with CI include auditory threshold,IT-MAIS/MAIS, CAP, SIR, MESP. The outcomes of 40 cases with GJB2-associated NSSNHL were compared 80 patients with negative results of screening of gene mutation (control group).Result: In comparison with control group,the auditory threshold in children with GJB2-associated NSSNH is better, however had no significant difference in other tests (P>0.05).Conclusion: CI could be performed on children with GJB2-associated NSSNHL.Postoperative outcomes of hearing and speech were satisfied.
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Key words:
- GJB2 gene /
- cochlear implantation
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