基质金属蛋白酶-9基因多态性与喉癌易感性及预后的研究

沈晓辉; 汤夏冰; 王俊国; 高下

doi:10.13201/j.issn.1001-1781.2014.12.013

基质金属蛋白酶-9基因多态性与喉癌易感性及预后的研究

- 1. 南京大学医学院附属鼓楼医院耳鼻咽喉头颈外科(南京, 210008);
- 2. 无锡市第一人民医院耳鼻咽喉头颈外科
基金项目:
南京市医学科技发展项目基金资助（No：YKK11099）

详细信息

通讯作者: 高下,E-mail:xiagaogao@hotmail.com

中图分类号: R739.65

收稿日期: 2013-10-12

Correlation of MMP-9 polymorphism with susceptibility and prognosis of laryngeal carcinoma

- 1. Department of Otolaryngology Head and Neck Surgery, Drum Tower Hospital Affiliated to Nanjing University School of Medicine, Nanjing, 210008, China;
- 2. Department of Otolaryngology Head and Neck Surgery, Wuxi People's Hospital

More Information

Corresponding author: GAO Xia, E-mail: xiagaogao@hotmail.com

Received Date: 12 October 2013

摘要

摘要: 目的：探讨MMP-9基因多态性与喉癌易感性及临床病理特征和预后的关系。方法：应用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法，检测142例喉癌患者和200例健康对照者MMP-9-1562C/T单核苷酸多态性位点的基因型。结果：携带MMP-9-1562CC基因型者患喉癌的风险高于携带MMP-9-1562CT/TT基因型者（P<0.05，95%CI=1.02~2.77）；MMP-9-1562C/T基因多态性与喉癌患者年龄、性别、T分期、临床分期及淋巴结转移无相关性；Kaplan-Meier生存分析结果显示，MMP-9-1562CC基因型患者的生存率低于TT和CT基因型患者（P<0.01）；COX回归分析显示，携带MMP-9-1562CC基因型的患者预后不良。结论：MMP-9-1562C/T基因多态性与喉癌的发病风险相关；MMP-9-1562C/T基因多态性可能是影响预后的独立危险因素。
- 喉肿瘤 /
- 基质金属蛋白酶类 /
- 基因多态性 /
- 预后
Abstract: Objective: To investigate the correlation of MMP-9 single nucleotide polymorphism(SNP) with susceptibility, clinicopathological characteristics and prognosis of laryngeal carcinoma. Method: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the MMP-9-1562C/T SNP genotype in 142 patients with laryngeal carcinoma and 200 healthy controls. Result: The MMP-9-1562CC genotype significantly increased the risk for laryngeal carcinoma compared to MMP-9-1562CT/TT genotype(P<0.05, 95%CI=1.02~2.77). MMP-9-1562C/T polymorphism did not correlate to age, sex, T stage, N stage and clinical stage. Univariate analysis indicated that the overall survival rate in patients with MMP-9-1562CC genotype was lower than that in MMP-9-1562CT/TT genotype. Multivariate analysis indicated that the patients with MMP-9-1562CC genotype had unfavourable prognosis. Conclusion: MMP-9-1562C/T polymorphism was closely correlateed with the risk for laryngeal carcinoma, and it may be an independent prognostic factor.
- laryngeal neoplasms /
- matrix metalloproteinases /
- single nucleotide polymorphism /
- prognosis

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参考文献(8)

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