survivin和增殖细胞核抗原在鼻腔鼻窦内翻性乳头状瘤中的表达及临床意义

彭丽娜; 单春光; 冯志星; 杨莉晖

doi:10.13201/j.issn.1001-1781.2013.05.003

survivin和增殖细胞核抗原在鼻腔鼻窦内翻性乳头状瘤中的表达及临床意义

- 1 邯郸市中心医院耳鼻咽喉科(河北邯郸, 056000);
- 2 河北医科大学第二医院耳鼻咽喉科;
- 3 石家庄市中心医院耳鼻咽喉科

详细信息

通讯作者: 单春光,E-mail:shanchunguang@163.com

中图分类号: R739.6

收稿日期: 2012-10-26

Expression and significance of survivin and PCNA in sinonasal inverted papilloma

- 1 Department of Otolaryngology, the Central Hospital of Handan, Handan, 056000, China;
- 2 Department of Otolaryngology, the Second Affiliated Hospital of Hebei Medical University;
- 3 Department of Otolaryngology, the Central Hospital of Shijiazhuang

More Information

Corresponding author: SHAN Chunguang, E-mail: shanchunguang@163.com

Received Date: 26 October 2012

摘要

摘要: 目的: 研究survivin和增殖细胞核抗原(PCNA)在鼻腔鼻窦内翻性乳头状瘤(SNIP)的发生、增殖、复发和恶变过程中的表达及意义。方法: 选取10例正常鼻黏膜组织(NM组)、45例SNIP患者(SNIP组)及9例SNIP恶变患者(SNIP恶变组)为研究对象,用免疫组织化学PV法分别进行survivin和PCNA的检测。结果: survivin和PCNA在NM组、SNIP组、SNIP恶变组中的表达均逐次增强,差异有统计学意义(均P<0.05)。但在SNIP中survivin和PCNA的表达差异无统计学意义(r=0.135,P>0.05)。结论: survivin和PCNA与SNIP的发病及恶变有关。
- 鼻腔鼻窦内翻性乳头状瘤 /
- survivin /
- 增殖细胞核抗原
Abstract: Objective: To explore the expression and significance of survivin and proliferating cell nuclear antigen(PCNA) on the occurrence, proliferation, recurrence and carcinogenesis of the sinonasal inverted papilloma(SNIP). Method: Immunohistochemical method was used to detect the expression of survivin and PCNA in 10 cases of nasal cavity mucosal(NM),45 cases of SNIP and 9 cases of canceration SNIP.Result: The positive expression of survivin and PCNA increased gradually in NM,SNIP and canceration PCNA group, and there were significant difference between the three groups. But there was no correlation between survivin and PCNA in the tissue of SNIP(r=0.135,P>0.05).Conclusion: Survivin and PCNA are involved in the growth and carcinogenesis of SNIP.
- sinonasal inverted papilloma /
- survivin /
- proliferating cell nuclear antigen

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