喉癌患者CEA、Cyfra21-1、SCC检测与临床病理指标关系

饶丽华; 张茏; 田令; 鄢金蓉; 向湘元; 余发斌

doi:10.13201/j.issn.1001-1781.2017.15.010

喉癌患者CEA、Cyfra21-1、SCC检测与临床病理指标关系

- 1. 宜昌市第二人民医院耳鼻咽喉头颈外科肿瘤微环境与免疫治疗湖北省重点实验室(湖北宜昌, 443000);
- 2. 宜昌市中心医院耳鼻咽喉头颈外科;
- 3. 宜昌市第二人民医院检验科;
- 4. 宜昌市第二人民医院肿瘤外科
基金项目:
肿瘤微环境与免疫治疗湖北省重点实验室开放基金项目（No：2017KZL03）

详细信息

通讯作者: 余发斌,E-mail:yczyrlh@163.com

中图分类号: R739.65

收稿日期: 2017-05-26

The clinical signifinace of CEA, Cyfra21-1 and SCC in laryngeal carcinoma's clinicopathological parameters

- 1. Department of Otolaryngology Head and Neck Surgery, the Second Hospital of Yichang, Yichang, 443000, China;
- 2. Department of Otolaryngology Head and Neck Surgery, the Central Hospital of Yichang;
- 3. Department of Clinical Laboratory, the Second Hospital of Yichang;
- 4. Department of Oncology Surgery, the Second Hospital of Yichang

More Information

Corresponding author: YU Fabin, E-mail: yczyrlh@163.com

Received Date: 26 May 2017

摘要

摘要: 目的：探讨喉癌患者血清中癌胚抗原（CEA），细胞角蛋白片段21-1（Cyfra21-1），鳞状细胞癌抗原（SCC）与喉癌各临床病理指标的关系及意义。方法：选取喉癌手术患者53例，术前常规检测血清CEA、Cyfra21-1、SCC，统计分析其与喉癌患者的年龄、原发灶（T分期）、淋巴结转移（N分期）、复发转移等临床指标的关系。结果：患者按年龄 ≤ 60岁与>60岁、有淋巴结转移与无淋巴结转移、有无复发转移、T1+T2与T3+T4进行分组，进行两样本均数t检验，结果表明：CEA与患者复发转移的关系有统计学意义（P=0.047），CEA升高时提示更容易复发或转移，CEA与患者的原发灶（P=0.252）、淋巴结转移（P=0.268）的关系无统计学意义；Cyfra21-1与原发灶的关系无统计学意义（P=0.402），与淋巴结转移的关系有统计学意义（P=0.041），淋巴结转移时Cyfra21-1升高，与术后复发转移有统计学意义（P=0.027），Cyfra21-1升高时提示更容易复发或转移；SCC与原发灶的关系无统计学意义（P=0.051），与淋巴结转移的关系有统计学意义（P=0.022），淋巴结转移时SCC升高，与术后复发转移有显著统计学意义（P=0.000），SCC升高时提示更容易复发或转移。Logistic多因素回归分析结果：CEA、Cyfra21-1、SCC与患者术后复发的关系均有统计学意义（P<0.05），而与患者的年龄、原发灶、淋巴结转移的关系均无统计学意义（P>0.05）。结论：喉癌血清Cyfra21-1、SCC升高提示患者更容易出现淋巴结转移及术后复发转移，CEA、Cyfra21-1、SCC是患者术后复发转移的独立预知因子，术前CEA、Cyfra21-1、SCC值升高提示患者术后更容易出现复发及转移。
- 喉肿瘤 /
- 癌胚抗原 /
- 细胞角蛋白片段21-1 /
- 鳞状细胞癌抗原
Abstract: Objective: To investigate the clinical signifinace of carcinoembryonic antigen(CEA),cytokeratin fragment 21-1(Cyfra21-1) or squamous cell carcinoma antigen(SCC) in laryngeal carcinoma's clinicopathological parametersthe.Method: CEA, Cyfra21-1, SCC in 53 laryngeal cancer's serum were routine preoperative detected to analyze the relationships between the tumor makers and the patient's age, primary tumor(T staging), lymph node metastasis(N staging), recurrence and metastasis.Result: According to age less than or equal to 60 years old and older than 60 years, lymph node metastasis or not lymph node metastasis, with or not with recurrence and metastasis and the T1+T2 and T3+T4 staging, the patients were divided into two groups. T test show that CEA was statistically significant in recurrence and metastasis(P=0.047) and it is more prone to recurrence and metastasis, but CEA was not statistically significant in primary tumor(P=0.252),lymph node metastasis(P=0.268). Cyfra21-1 was not statistically significant in primary range(P=0.402) but was statistically in lymph node metastasis(P=0.041).While the lymph node metastasis, it is more prone to recurrence and metastasis in laryngeal cancer patients with Cyfra21-1's increasing(P=0.027).SCC was not significant in primary lesions(P=0.051),but was statistically significant in lymph node metastasis(P=0.022). While lymph node metastasis, it is more prone to recurrence and metastasis in laryngeal cancer patients with SCC's increasing(P=0.000). Logistic multivariate regression analization show that CEA,Cyfra21-1 and SCC were statistically significant in the recurrence and postoperative of laryngeal patients(P<0.05) but not in the age of patient, primary tumor, the relationship and lymph node metastasis(P>0.05).Conclusion: It is more prone to occurrence lymph node metastasis and recurrence and metastasis in the postoperative serum of laryngeal cancer patients with Cyfra21-1, SCC. CEA and Cyfra21-1 increasing. SCC were independent predictive factor of recurrence and metastasis after surgery. It is more prone to recurrence and metastasis after surgery in the laryngeal cancer patients with CEA, Cyfra21-1 and SCC preoperative increasing.
- laryngeal neoplasms /
- carcinoembryonic antigen /
- cytokeratin fragment 21-1 /
- squamous cell carcinoma antigen

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