X射线交错互补修复基因3基因单体型与喉癌的关联分析

周旭; 戚颖

doi:10.13201/j.issn.1001-1781.2014.21.007

X射线交错互补修复基因3基因单体型与喉癌的关联分析

周旭^,,
戚颖

- 复旦大学附属中山医院耳鼻咽喉科(上海, 200032)

详细信息

通讯作者: 周旭,E-mail:x_zhou2005@aliyun.com

中图分类号: R739.6

收稿日期: 2014-06-01

Haplotype analysis of XRCC3 gene and laryngeal

ZHOU Xu^,,
QI Ying

- Department of Otolaryngology, the Zhongshan Hospital of Fudan University, Shanghai, 200032, China

More Information

Corresponding author: ZHOU Xu, E-mail: x_zhou2005@aliyun.com

Received Date: 01 June 2014

摘要

摘要: 目的:探讨X射线交错互补修复基因3(XRCC3)基因单体型和喉癌易感性的关联。方法:选择XRCC3基因4个标签SNP(rs12432907、rs861536、rs861537、rs861531),对310例喉癌患者(实验组)及310例健康人(对照组)进行基因分型。采用SHEsis软件构建单体型,比较基因型及单体型频率在2组之间的差异。结果:实验组、对照组rs12432907基因型频率比较,差异有统计学意义(P<0.05)。单体型分析结果显示, CCAG单体型分布频率实验组明显高于对照组,TCAG和TTAG分布频率实验组明显低于对照组,差异有统计学意义(均P<0.05)。结论:XRCC3基因单体型和喉癌的易感性具有明显关联。
- X射线交错互补修复基因3 /
- 喉肿瘤 /
- 单体型 /
- 单核苷酸多态性
Abstract: Objective:To explore the association of XRCC3 gene polymorphisms and haplotypes with laryngeal.Method:We selected 4 tag SNPs (rs12432907,rs861536,rs861537,rs861531,rs861531) for the present study.310 laryngeal patients and 310 healthy control subject were genotyping.The distribution of genotypes and haplotypes in these two group was compared.Result:The distributions of rs12432907 was significantly different between these two groups.The CCAG haplotype frequency was higher in laryngeal group than that in control group.But TCAG and TTAG haplotype frequency was were lower in the laryngeal patient than that those in the control subject.Conclusion:XRCC3 gene polymorphism was associated with the risk of laryngeal patients.
- XRCC3 gene /
- laryngeal carcinoma /
- haplotype /
- single nucleotide polymorphism

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