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摘要: 慢性鼻窦炎伴鼻息肉是常见的慢性炎性疾病，伴有明显的组织重塑，其重塑机制尚不明确。研究发现T2型炎症网络在组织重塑及鼻息肉形成过程中发挥至关重要的作用，并已针对多个生物靶点开展临床试验，还有若干潜在的治疗靶点受到越来越多的关注。本文将归纳总结T2型炎症反应参与鼻息肉组织重塑的研究进展，以期为进一步探究鼻息肉组织重塑的发生机制提供思路。Abstract: Chronic rhinosinusitis with nasal polyps is a common chronic inflammatory disease with significant tissue remodeling, but the mechanism of remodeling remains unclear. Studies have shown that Type(T) 2 inflammatory network plays a crucial role in tissue remodeling and nasal polyp formation. Clinical trials have been carried out for several biological targets, and a number of potential therapeutic targets have received increasing attention. This paper will summarize the research progress of T2 inflammatory response involved in nasal polyp tissue remodeling to provide ideas for further exploring the mechanism of nasal polyp tissue remodeling.
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