Research progress on correlation between childhood obesity and obstructive sleep apnea
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摘要: 儿童肥胖的患病率正在逐渐增加，在世界范围内女童的肥胖患病率为5.6%，男童为7.8%。这同时导致肥胖相关疾病发病率也相应增加，尤其是阻塞性睡眠呼吸暂停(obstructive sleep apnea，OSA)。肥胖是儿童OSA的独立危险因素和调节因子。儿童OSA和肥胖之间存在一种双向因果关系。在儿童OSA和肥胖之间的联系中，涉及的因素包括炎症反应、氧化应激和肠道菌群等。然而，肥胖相关的炎症反应与OSA发病机制之间的因果关系仍需进一步研究，本综述就儿童肥胖与OSA的相关性进行探讨。Abstract: Prevalence of childhood obesity is progressively increasing, reaching worldwide levels of 5.6% in girls and of 7.8% in boys. This also leads to a corresponding increase in the prevalence of obesity-associated morbidities particularly those involving obstructive sleep apnea(OSA). Obesity is an independent risk factor and regulator of OSA in children. There is a bidirectional causal relationship between OSA and obesity in children. The factors involved in the association between OSA and obesity are systemic inflammation, oxidative stress, and gut microbiota etc. However, a causal link between obesity-related inflammatory state and OSA pathogenesis still needs to be properly confirmed. The present review aimed to investigate the links between childhood obesity and OSA.
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Key words:
- obstructive sleep apnea /
- child /
- obesity
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