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摘要: 目的探讨再次手术对接受甲状旁腺全切除加自体移植术(PTX+AT)治疗继发性甲状旁腺功能亢进(SHPT)后出现SHPT术后持续(PHPT)患者的疗效。方法回顾性分析北京大学民航临床医学院耳鼻咽喉头颈外科2012年8月—2021年12月行再手术治疗的18例接受PTX+AT术后出现PHPT患者的临床资料，术前通过联合颈部彩色多普勒超声、核素显像、增强CT、MR四种影像学检查对前次手术遗留的甲状旁腺进行定位，再次手术时参照影像学结果切除遗留原位甲状旁腺，并按照清扫式甲状旁腺切除理念扩大手术探查范围，切除遗漏的异位旁腺或额外旁腺。比较术前与术后多时段血清全段甲状旁腺激素(i-PTH)变化，观察术后临床症状改善情况及术后并发症发生情况以评价治疗效果。结果所有患者均成功手术，共切除30枚甲状旁腺，均经术后病理再次确认，其中颈部原位甲状旁腺16枚，异位甲状旁腺14枚(其中异位于上纵隔5枚、胸腺4枚、后纵隔2枚、甲状腺实质内2枚、颈鞘内1枚)。术后6 h患者骨关节痛、皮肤瘙痒明显缓解甚至消失; 术后1周血清i-PTH、钙磷指标均达标，肌无力明显改善; 16例患者术后发生低钙血症，经补钙后均缓解; 6例出现短暂性声嘶。未出现严重并发症及死亡病例。术后随访1年无复发。结论再次手术是SHPT术后持续状态的首选治疗方法，术中按照清扫式甲状旁腺切除理念扩大手术范围，成功率高、并发症少，能有效提高患者生活质量和长期生存率。
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关键词:
- 继发性甲状旁腺功能亢进 /
- 甲状旁腺全切除 /
- 自体移植术 /
- 再手术
Abstract: ObjectiveTo evaluate the clinical effect of reoperation in persistent hyperparathyroidism (PHPT) patients after operation of parathyroidectomy combined with autotransplantation(PTX+AT) on secondary hyperparathyroidism (SHPT).Methods18 PHPT patients who treated with reoperation after PTX+AT were enrolled in this study during the period from Aug 2012 to Dec 2021 in the Department of Otolaryngology Head and Neck Surgery of Peking University Civil Aviation School of Clinical Medicine, Civil Aviation General Hospital. The remaining parathyroid glands were located by preoperative colour Doppler ultrasonography, radionuclide imaging, enhanced CT and MR imaging in the neck region. Based on the imaging findings, the remaining parathyroid glands were removed in situ, and the missed ectopic or extra parathyroid glands were resected with an extended surgical scope according to the parathyroid dissection method. The surgical effect was evaluated by the changes of clinical symptoms, the dynamic change of serum intact paramyroidhomone(i-PTH) between preoperative and postoperative periods and the surgical complications.ResultsAll the 18 patients accepted successful operation. 30 parathyroid glands were resected confirmed by postoperative pathology, including 16 in situ and 14 ectopic glands(5 in superior mediastinum, 4 in thymus, 2 in posterior mediastinum, 2 in thyroid glands, 1 in carotid sheath).Osteoarthropathy and skin itching were significantly relieved or even disappeared at 6 h after surgery. The levels of serum i-PTH, calcium and phosphorus reached the standards and muscle weakness was significantly improved 1 week after surgery. 16 patients presented hypocalcemia and returned to normal after supplement of calcium. Hoarseness due to temporary injury of laryngeal nerve was found in 6 cases. No serious complications or death occurred after the operation.There was no recurrence after 1 year follow-up.ConclusionReoperation is the first choice for SHPT patients complicated with persistent hyperparathyroidism. Multiple imaging examinations are used to locate the residual parathyroid, especially the ectopic gland. Expanded surgical scope is applied to resect all the residual parathyroid glands(ectopic, in situ and concealed parathyroid) according to the concept of dissection parathyroidectomy. The surgery is effective and safe. Patients'quality of life and long-term survival rate is improved.-
Key words:
- secondary hyperparathyroidism /
- parathyroidectomy /
- autotransplantation /
- reoperation
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图 1 99Tcm-MIBI显像 1a：轴状位; 1b：冠状位; 1c：矢状位; SPECT/CT融合显像示十字叉处核素浓聚灶位于甲状腺右叶中部后方; 图 2 多排螺旋CT增强扫描图像 2a：轴状位; 2b：冠状位; 白箭头示甲状旁腺位于右气管食管沟后方间隙内; 图 3 MR所示 3a：T2WI轴状位抑脂图像，3b：T2WI冠状位抑脂图像，3c：T1WI冠状位图像; 白箭头指示为增生甲状旁腺，位于甲状腺右叶中部后方食管旁间隙，10 mm×9 mm×7 mm大小。
表 1 术后1周生化指标变化情况(n=18)
时间 血钙/(mmol·L-1) 血磷/(mmol·L-1) 钙磷乘积/(mg2·dL-2) 血红蛋白/(g·L-1) 红细胞比容/% 术前 2.41±0.28 2.18±0.52 66.78±16.94 123.78±20.69 38.76±7.57 术后 1.94±0.35 1.83±0.61 44.47±15.94 121.46±19.75 36.88±6.89 t值 6.547 2.568 4.574 1.065 1.753 P值 < 0.001 0.037 < 0.001 0.321 0.138 
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