Research progress on the relationship between lncRNA and the pathogenesis of allergic rhinitis
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Abstract: Long non-coding RNA(lncRNA) belongs to the category of non-coding RNA, which length exceeds 200 nucleotides and can hardly encode the expression of proteins. Based on the data from several clinical researches, it is considered that lncRNA not only plays the biological role in epigenetics, transcriptional and post-transcriptional levels, but also abnormally expresses in inflammatory response and the related diseases. In recent years, with the intensive study of gene expression regulation of allergic rhinitis(AR), it has been found that a variety of non-coding RNA, including lncRNA, have close relationship with the occurrence and development of AR. This review mainly summarized the biological function, immunomodulatory effect of lncRNA and the relationship between the lncRNA and the pathogenesis of AR, providing new thoughts and strategies for the further research, prevention as well as the treatment of AR.
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Key words:
- rhinitis, allergic /
- long non-coding RNA /
- immunomodulation /
- genetic expression
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表 2 lncRNA在AR不同组织中的作用
参考文献 lncRNA 作用 组织 Zhu等[36] lncGAS5 抑制Th1分化、促进Th2分化 鼻黏膜 Ma等[44] lnc-RAD9B-1、ENST00000505668 维持鼻黏膜正常功能 鼻黏膜 Zhu等[45] lncGAS5 使GATA3表达下调、减轻AR症状 鼻黏膜 Yue等[46] lncRNA-linc00632 诱导炎性细胞因子和黏液的产生 鼻黏膜 Qian等[47] lncRNA ANRIL 促进炎性因子合成和释放、激活B细胞免疫反应 鼻黏膜 Liu等[48] lncRNA ANRIL 抑制IL-13诱导的鼻黏膜上皮组织产生炎性细胞因子和粘蛋白 鼻黏膜 Wang等[49] lncRNA(NONMMUT057309)、lncRNA(NONMMUT016103) 调节鼻黏膜免疫球蛋白的表达、影响鼻黏膜的变态反应 鼻黏膜 杨烨[50] lnc-RTL1 参与AR的发生 鼻黏膜 Yang等[51] ENST00000445003.1、ENST00000456563.1、ENST00000609268.1、HIT000095414_04 参与免疫炎症反应 外周血 Ma等[52] FR022494、FR255904、FR16947、FR288904、FR285768、FR301516 差异性表达的lncRNA在AR的T细胞分化过程中发挥调控作用 脾脏 IL：白细胞介素；GATA：基因启动子的一段保守序列。 
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[1] Zhang Y, Zhang L. Increasing Prevalence of Allergic Rhinitis in China[J]. Allergy Asthma Immunol Res, 2019, 11(2): 156-169. doi: 10.4168/aair.2019.11.2.156
[2] Cheng L, Chen J, Fu Q, et al. Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis[J]. Allergy Asthma Immunol Res, 2018, 10(4): 300-353. doi: 10.4168/aair.2018.10.4.300
[3] Kirtland ME, Tsitoura DC, Durham SR, et al. Toll-Like Receptor Agonists as Adjuvants for Allergen Immunotherapy[J]. Front Immunol, 2020, 11: 599083. doi: 10.3389/fimmu.2020.599083
[4] Bousquet J, Anto JM, Bachert C, et al. Allergic rhinitis[J]. Nat Rev Dis Primers, 2020, 6(1): 95. doi: 10.1038/s41572-020-00227-0
[5] 李巧玉, 郑国玺. 布地奈德鼻喷雾剂对过敏性鼻炎患者Th1/Th2细胞因子的影响及疗效观察[J]. 河北医学, 2016, 22(4): 538-540. doi: 10.3969/j.issn.1006-6233.2016.04.004
[6] Vocca L, Di Sano C, Uasuf CG, et al. IL-33/ST2 axis controls Th2/IL-31 and Th17 immune response in allergic airway diseases[J]. Immunobiology, 2015, 220(8): 954-963. doi: 10.1016/j.imbio.2015.02.005
[7] Chen X, Yan CC, Zhang X, et al. Long non-coding RNAs and complex diseases: from experimental results to computational models[J]. Brief Bioinform, 2017, 18(4): 558-576.
[8] Atianand MK, Fitzgerald KA. Long non-coding RNAs and control of gene expression in the immune system[J]. Trends Mol Med, 2014, 20(11): 623-631. doi: 10.1016/j.molmed.2014.09.002
[9] Kour S, Rath PC. Long noncoding RNAs in aging and age-related diseases[J]. Ageing Res Rev, 2016, 26: 1-21. doi: 10.1016/j.arr.2015.12.001
[10] Joslyn RC, Forero A, Green R, et al. Long Noncoding RNA Signatures Induced by Toll-Like Receptor 7 and Type I Interferon Signaling in Activated Human Plasmacytoid Dendritic Cells[J]. J Interferon Cytokine Res, 2018, 38(9): 388-405. doi: 10.1089/jir.2018.0086
[11] Espinoza CA, Goodrich JA, Kugel JF. Characterization of the structure, function, and mechanism of B2 RNA, an ncRNA repressor of RNA polymerase Ⅱ transcription[J]. RNA, 2007, 13(4): 583-596. doi: 10.1261/rna.310307
[12] Kaessmann H. Origins, evolution, and phenotypic impact of new genes[J]. Genome Res, 2010, 20(10): 1313-1326. doi: 10.1101/gr.101386.109
[13] Deforges J, Reis RS, Jacquet P, et al. Prediction of regulatory long intergenic non-coding RNAs acting in trans through base-pairing interactions[J]. BMC Genomics, 2019, 20(1): 601. doi: 10.1186/s12864-019-5946-0
[14] Kung JT, Colognori D, Lee JT. Long noncoding RNAs: past, present, and future[J]. Genetics, 2013, 193(3): 651-669. doi: 10.1534/genetics.112.146704
[15] Arney KL. H19 and Igf2--enhancing the confusion?[J]. Trends Genet, 2003, 19(1): 17-23. doi: 10.1016/S0168-9525(02)00004-5
[16] Zhou J, Yang L, Zhong T, et al. H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase[J]. Nat Commun, 2015, 6: 10221. doi: 10.1038/ncomms10221
[17] Ding G, Li W, Liu J, et al. lncRNA GHET1 activated by H3K27 acetylation promotes cell tumorigenesis through regulating ATF1 in hepatocellular carcinoma[J]. Biomed Pharmacother, 2017, 94: 326-331. doi: 10.1016/j.biopha.2017.07.046
[18] 程立, 陈立彩, 马锐, 等. 预测及分析长链非编码RNA HOTAIR的分子调控通路[J]. 湖北医药学院学报, 2015, 34(1): 16-22. https://www.cnki.com.cn/Article/CJFDTOTAL-YYYX201501004.htm
[19] 杨敏, 杨再兴. 长链非编码RNA在免疫系统中的研究进展[J]. 国际检验医学杂志, 2013, 34(24): 3373-3375. https://www.cnki.com.cn/Article/CJFDTOTAL-SHYY201510023.htm
[20] Aune TM, Spurlock CF 3rd. Long non-coding RNAs in innate and adaptive immunity[J]. Virus Res, 2016, 212: 146-160. doi: 10.1016/j.virusres.2015.07.003
[21] Guttman M, Amit I, Garber M, et al. Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals[J]. Nature, 2009, 458(7235): 223-227. doi: 10.1038/nature07672
[22] Carpenter S, Aiello D, Atianand MK, et al. A long noncoding RNA mediates both activation and repression of immune response genes[J]. Science, 2013, 341(6147): 789-792. doi: 10.1126/science.1240925
[23] Hu G, Gong AY, Wang Y, et al. LincRNA-Cox2 Promotes Late Inflammatory Gene Transcription in Macrophages through Modulating SWI/SNF-Mediated Chromatin Remodeling[J]. J Immunol, 2016, 196(6): 2799-2808. doi: 10.4049/jimmunol.1502146
[24] Wang P, Xue Y, Han Y, et al. The STAT3-binding long noncoding RNA lnc-DC controls human dendritic cell differentiation[J]. Science, 2014, 344(6181): 310-313. doi: 10.1126/science.1251456
[25] Zhang X, Lian Z, Padden C, et al. A myelopoiesis-associated regulatory intergenic noncoding RNA transcript within the human HOXA cluster[J]. Blood, 2009, 113(11): 2526-2534. doi: 10.1182/blood-2008-06-162164
[26] Ranzani V, Rossetti G, Panzeri I, et al. The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4[J]. Nat Immunol, 2015, 16(3): 318-325. doi: 10.1038/ni.3093
[27] Pagani M, Rossetti G, Panzeri I, et al. Role of microRNAs and long-non-coding RNAs in CD4(+)T-cell differentiation[J]. Immunol Rev, 2013, 253(1): 82-96. doi: 10.1111/imr.12055
[28] Petri A, Dybkær K, Bøgsted M, et al. Long Noncoding RNA Expression during Human B-Cell Development[J]. PLoS One, 2015, 10(9): e0138236. doi: 10.1371/journal.pone.0138236
[29] Peng W, Wu J, Feng J. LincRNA-p21 predicts favorable clinical outcome and impairs tumorigenesis in diffuse large B cell lymphoma patients treated with R-CHOP chemotherapy[J]. Clin Exp Med, 2017, 17(1): 1-8. doi: 10.1007/s10238-015-0396-8
[30] Zhang GQ, Hu HJ, Liu CY, et al. Probiotics for Prevention of Atopy and Food Hypersensitivity in Early Childhood: A PRISMA-Compliant Systematic Review and Meta-Analysis of Randomized Controlled Trials[J]. Medicine(Baltimore), 2016, 95(8): e2562.
[31] Zhang J, Zhu Y, Wang R. Long noncoding RNAs in respiratory diseases[J]. Histol Histopathol, 2018, 33(8): 747-756.
[32] 冯明玉, 韦平, 倪琼秀, 等. 小儿哮喘患者血清中lncRNA BCYRN1的表达及临床意义[J]. 中国当代医药, 2017, 24(11): 9-12. doi: 10.3969/j.issn.1674-4721.2017.11.003
[33] 孙淑宁, 乔建瓯, 韩肇庆. 在树突状细胞中筛选与呼吸道合胞病毒诱发哮喘相关的长链非编码RNAs[J]. 广东医学, 2017, 38(21): 3229-3234. doi: 10.3969/j.issn.1001-9448.2017.21.001
[34] Austin PJ, Tsitsiou E, Boardman C, et al. Transcriptional profiling identifies the long noncoding RNA plasmacytoma variant translocation(PVT1) as a novel regulator of the asthmatic phenotype in human airway smooth muscle[J]. J Allergy Clin Immunol, 2017, 139(3): 780-789. doi: 10.1016/j.jaci.2016.06.014
[35] Keenan CR, Schuliga MJ, Stewart AG. Pro-inflammatory mediators increase levels of the noncoding RNA GAS5 in airway smooth muscle and epithelial cells[J]. Can J Physiol Pharmacol, 2015, 93(3): 203-206. doi: 10.1139/cjpp-2014-0391
[36] Zhu X, Wang X, Wang Y, et al. Exosomal long non-coding RNA GAS5 suppresses Th1 differentiation and promotes Th2 differentiation via downregulating EZH2 and T-bet in allergic rhinitis[J]. Mol Immunol, 2020, 118: 30-39. doi: 10.1016/j.molimm.2019.11.009
[37] 蔡诗茹, 娄鸿飞. 变应性鼻炎的神经免疫调节机制[J]. 临床耳鼻咽喉头颈外科杂志, 2021, 35(9): 859-864. https://www.cnki.com.cn/Article/CJFDTOTAL-LCEH202109022.htm
[38] 季洁, 张小兵. 非编码RNA在变应性鼻炎病程中的作用[J]. 中国医学文摘-耳鼻咽喉科学, 2017, 32(6): 375-378. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYEB201706028.htm
[39] 罗子华, 于晓峰, 邹健. 非编码RNA对肿瘤的调控机制[J]. 国际消化病杂志, 2013, 33(2): 97-100. doi: 10.3969/j.issn.1673-534X.2013.02.008
[40] Shi W, Wang Q, Bian Y, et al. Long noncoding RNA PANDA promotes esophageal squamous carcinoma cell progress by dissociating from NF-YA but interact with SAFA[J]. Pathol Res Pract, 2019, 215(10): 152604. doi: 10.1016/j.prp.2019.152604
[41] Zhang H, Nestor CE, Zhao S, et al. Profiling of human CD4+ T-cell subsets identifies the TH2-specific noncoding RNA GATA3-AS1[J]. J Allergy Clin Immunol, 2013, 132(4): 1005-1008. doi: 10.1016/j.jaci.2013.05.033
[42] Collier SP, Collins PL, Williams CL, et al. Cutting edge: influence of Tmevpg1, a long intergenic noncoding RNA, on the expression of Ifng by Th1 cells[J]. J Immunol, 2012, 189(5): 2084-2088. doi: 10.4049/jimmunol.1200774
[43] Cui H, Xie N, Tan Z, et al. The human long noncoding RNA lnc-IL7R regulates the inflammatory response[J]. Eur J Immunol, 2014, 44(7): 2085-2095. doi: 10.1002/eji.201344126
[44] Ma Z, Teng Y, Liu X, et al. Identification and Functional Profiling of Differentially Expressed Long Non-Coding RNAs in Nasal Mucosa with Allergic Rhinitis[J]. Tohoku J Exp Med, 2017, 242(2): 143-150. doi: 10.1620/tjem.242.143
[45] Zhu X, Wang X, Wang Y, et al. The regulatory network among CircHIPK3, LncGAS5, and miR-495 promotes Th2 differentiation in allergic rhinitis[J]. Cell Death Dis, 2020, 11(4): 216. doi: 10.1038/s41419-020-2394-3
[46] Yue L, Yin X, Hao F, et al. Long Noncoding RNA Linc00632 Inhibits Interleukin-13-Induced Inflammatory Cytokine and Mucus Production in Nasal Epithelial Cells[J]. J Innate Immun, 2020, 12(1): 116-128. doi: 10.1159/000500420
[47] Qian X, Shi S, Zhang G. Long non-coding RNA antisense non-coding RNA in the INK4 locus expression correlates with increased disease risk, severity, and inflammation of allergic rhinitis[J]. Medicine(Baltimore), 2019, 98(20): e15247.
[48] Liu HW, Hu ZL, Li H, et al. Knockdown of lncRNA ANRIL suppresses the production of inflammatory cytokines and mucin 5AC in nasal epithelial cells via the miR-15a-5p/JAK2 axis[J]. Mol Med Rep, 2021, 23(2): 145.
[49] Wang J, Cui M, Sun F, et al. HDAC inhibitor sodium butyrate prevents allergic rhinitis and alters lncRNA and mRNA expression profiles in the nasal mucosa of mice[J]. Int J Mol Med, 2020, 45(4): 1150-1162.
[50] 杨烨. 变应性鼻炎鼻黏膜组织中长链非编码RNA-RTL1表达与变应性鼻炎相关临床指标的相关性研究[D]. 杭州: 浙江中医药大学, 2020.
[51] Yang Y, Zhang Y, Yang Y, et al. Differential Expression of Long Noncoding RNAs and Their Function-Related mRNAs in the Peripheral Blood of Allergic Rhinitis Patients[J]. Am J Rhinol Allergy, 2020, 34(4): 508-518. doi: 10.1177/1945892420912164
[52] Ma Y, Shi L, Zheng C. Microarray analysis of lncRNA and mRNA expression profiles in mice with allergic rhinitis[J]. Int J Pediatr Otorhinolaryngol, 2018, 104: 58-65. doi: 10.1016/j.ijporl.2017.10.046
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