胰岛素样生长因子-1对内耳保护机制的研究进展

吴婷; 徐聪; 孙岩

doi:10.13201/j.issn.2096-7993.2021.06.020

胰岛素样生长因子-1对内耳保护机制的研究进展

- 1.
  青岛大学附属烟台毓璜顶医院耳鼻咽喉头颈外科(山东烟台，264000)
- 2.
  滨州医学院

详细信息

通讯作者: 孙岩，E-mail：lenards@163.com

中图分类号: R764.43

收稿日期: 2020-06-30

刊出日期: 2021-06-05

Research progress on the protective mechanism of insulin like growth factor-1 on inner ear

More Information

Corresponding author: SUN Yan, E-mail: lenards@163.com

Received Date: 30 June 2020

Publish Date: 05 June 2021

摘要

- 胰岛素样生长因子-1 /
- 毛细胞 /
- 螺旋神经节 /
- 感音神经性聋
Abstract: As one of the neurotrophic factors and insulin family, insulin like growth factor-1(IGF-1) can promote cell synthesis and metabolism in tissues and organs, activate cell growth, proliferation and differentiation, and inhibit cell apoptosis.Sensorineural hearing loss is the most common manifestation of the inner ear disease, which is mainly caused by the damage of cochlear hair cells.The lack of IGF-1 directly affects the growth, development and differentiation of cochlear hair cells, thus IGF-1 participates in the maintenance of cell survival and repair during inner ear cell injury.This article systematically reviews the recent research progress on the protective mechanism of IGF-1 on the inner ear.
- insulin like growth factor-1 /
- hair cell /
- spiral ganglion /
- sensorineural hearing loss

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参考文献(46)

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