-
Abstract: Respiratory allergic disease mainly include asthma and allergic rhinitis.According to their extremely similarpathogenesis and inflammatory pathological changes, asthma and allergic rhinitis, are regarded as the concept of "one airway, one disease". In recent years, The research on the target of allergens in the pathogenesis mechanism is more in-depth, and the CCR3 gene is a major research target. The study found that the CCR3 gene is an important target gene for the development of respiratory allergic diseases such as allergic rhinitis and asthma. The related inflammatory cells are the main cells responding for the downstream cascade triggered by CCR3 activation, which directly or indirectly cause allergic inflammation through itself or its secretions.Therefore, researches on the roles of CCR3 gene and its related inflammatory cells become hot topics in the clinical treatment of respiratory allergic diseases. This paper reviews the current research progress of respiratory allergic diseases on the basis of intensive literature.
-
Key words:
- CCR3 /
- respiratory allergic disease /
- eosinophils /
- mast cells /
- basophils
-
-
[1] Zhang Y, Zhang L. Increasing Prevalence of Allergic Rhinitis in China[J]. Allergy Asthma Immunol Res, 2019, 11(2): 156-169. doi: 10.4168/aair.2019.11.2.156
[2] Tian L, Li W, Wang J, et al. The CKLF1-C19 peptide attenuates allergic lung inflammation by inhibiting CCR3-and CCR4-mediated chemotaxis in a mouse model of asthma[J]. Allergy, 2011, 66(2): 287-297. doi: 10.1111/j.1398-9995.2010.02478.x
[3] Grozdanovic M, Laffey KG, Abdelkarim H, et al. Novel peptide nanoparticle-biased antagonist of CCR3 blocks eosinophil recruitment and airway hyperresponsiveness[J]. J Allergy Clin Immunol, 2019, 143(2): 669-680. e12. doi: 10.1016/j.jaci.2018.05.003
[4] Pease JE, Williams TJ. Tipping the balance: A biased nanobody antagonist of CCR3 with potential for the treatment of eosinophilic inflammation[J]. J Allergy Clin Immunol, 2019, 143(2): 552-553. doi: 10.1016/j.jaci.2018.10.052
[5] White GE, Iqbal AJ, Greaves DR. CC chemokine receptors and chronic inflammation——therapeutic opportunities and pharmacological challenges[J]. Pharmacol Rev, 2013, 65(1): 47-89. doi: 10.1124/pr.111.005074
[6] Song Y, Ge B, Lao J, et al. Regulation of the Oligomeric Status of CCR3 with Binding Ligands Revealed by Single-Molecule Fluorescence Imaging[J]. Biochemistry, 2018, 57(5): 852-860. doi: 10.1021/acs.biochem.7b00676
[7] Zhu X, Liu K, Wang J, et al. C-C chemokine receptor type 3 gene knockout alleviates inflammatory responses in allergic rhinitis model mice by regulating the expression of eosinophil granule proteins and immune factors[J]. Mol Med Rep, 2018, 18(4): 3780-3790.
[8] Gauvreau GM, FitzGerald JM, Boulet LP, et al. The effects of a CCR3 inhibitor, AXP1275, on allergen-induced airway responses in adults with mild-to-moderate atopic asthma[J]. Clin Exp Allergy, 2018, 48(4): 445-451. doi: 10.1111/cea.13114
[9] Pease JE, Horuk R. Recent progress in the development of antagonists to the chemokine receptors CCR3 and CCR4[J]. Expert Opin Drug Discov, 2014, 9(5): 467-483. doi: 10.1517/17460441.2014.897324
[10] Varricchi G, Bagnasco D, Borriello F, et al. Interleukin-5 pathway inhibition in the treatment of eosinophilic respiratory disorders: evidence and unmet needs[J]. Curr Opin Allergy Clin Immunol, 2016, 16(2): 186-200. doi: 10.1097/ACI.0000000000000251
[11] 朱新华, 王嘉麟, 黄泉龙, 等. 敲除CCR3基因对小鼠Eos的作用实验观察[J]. 临床耳鼻咽喉头颈外科杂志, 2017, 31(24): 1913-1918. https://www.cnki.com.cn/Article/CJFDTOTAL-LCEH201724011.htm
[12] Lund SJ, Portillo A, Cavagnero K, et al. Leukotriene C4 Potentiates IL-33-Induced Group 2 Innate Lymphoid Cell Activation and Lung Inflammation[J]. J Immunol, 2017, 199(3): 1096-1104. doi: 10.4049/jimmunol.1601569
[13] Willetts L, Felix LC, Jacobsen EA, et al. Vesicle-associated membrane protein 7-mediated eosinophil degranulation promotes allergic airway inflammation in mice[J]. Commun Biol, 2018, 1: 83-83. doi: 10.1038/s42003-018-0081-z
[14] Nakagome K, Nagata M. Possible Mechanisms of Eosinophil Accumulation in Eosinophilic Pneumonia[J]. Biomolecules, 2020, 10(4): 638-638. doi: 10.3390/biom10040638
[15] Asosingh K, Vasanji A, Tipton A, et al. Eotaxin-Rich Proangiogenic Hematopoietic Progenitor Cells and CCR3+ Endothelium in the Atopic Asthmatic Response[J]. J Immunol, 2016, 196(5): 2377-2387. doi: 10.4049/jimmunol.1500770
[16] Song DJ, Shim MH, Lee N, et al. CCR3 Monoclonal Antibody Inhibits Eosinophilic Inflammation and Mucosal Injury in a Mouse Model of Eosinophilic Gastroenteritis[J]. Allergy Asthma Immunol Res, 2017, 9(4): 360-367. doi: 10.4168/aair.2017.9.4.360
[17] Kay AB. Paul Ehrlich and the Early History of Granulocytes[J]. Microbiol Spectr, 2016, 4(4): 1-1.
[18] Fukuishi N, Murakami S, Ohno A, et al. Does β-hexosaminidase function only as a degranulation indicator in mast cells? The primary role of β-hexosaminidase in mast cell granules[J]. J Immunol, 2014, 193(4): 1886-1894. doi: 10.4049/jimmunol.1302520
[19] Vitte J. Human mast cell tryptase in biology and medicine[J]. Mol Immunol, 2015, 63(1): 18-24. doi: 10.1016/j.molimm.2014.04.001
[20] Asosingh K, Hanson JD, Cheng G, et al. Allergen-induced, eotaxin-rich, proangiogenic bone marrow progenitors: a blood-borne cellular envoy for lung eosinophilia [J]. J Allergy Clin Immunol, 2010, 125(4): 918-925. doi: 10.1016/j.jaci.2010.01.017
[21] 彭海森. 肥大细胞在变应性鼻炎发病机制中的应用研究[J]. 临床耳鼻咽喉头颈外科杂志, 2018, 32(2): 157-160. https://www.cnki.com.cn/Article/CJFDTOTAL-LCEH201802021.htm
[22] 朱新华, 彭海森, 江银丽, 等. 慢病毒介导的小鼠CCR3基因RNAi载体的构建及其在肥大细胞中的表达[J]. 临床耳鼻咽喉头颈外科杂志, 2019, 33(7): 628-634. https://www.cnki.com.cn/Article/CJFDTOTAL-LCEH201907013.htm
[23] Mori A, Ogawa K, Kajiyama Y, et al. Th2-cell-mediated chemokine synthesis is involved in allergic airway inflammation in mice[J]. Int Arch Allergy Immunol, 2006, 140 Suppl 1: 55-58.
[24] Khanolkar A, Burden SJ, Hansen B, et al. Evaluation of CCR3 as a basophil activation marker[J]. Am J Clin Pathol, 2013, 140(3): 293-300. doi: 10.1309/AJCPLSN0RQKHJX1A
[25] He SH, Zhang HY, Zeng XN, et al. Mast cells and basophils are essential for allergies: mechanisms of allergic inflammation and a proposed procedure for diagnosis[J]. Acta Pharmacol Sin, 2013, 34(10): 1270-1283. doi: 10.1038/aps.2013.88
[26] Nakashima C, Otsuka A, Kitoh A, et al. Basophils regulate the recruitment of eosinophils in a murine model of irritant contact dermatitis[J]. J Allergy Clin Immunol, 2014, 134(1): 100-107. doi: 10.1016/j.jaci.2014.02.026
[27] Motomura Y, Morita H, Moro K, et al. Basophil-derived interleukin-4 controls the function of natural helper cells, a member of ILC2 s, in lung inflammation[J]. Immunity, 2014, 40(5): 758-771. doi: 10.1016/j.immuni.2014.04.013
[28] Cheng LE, Sullivan BM, Retana LE, et al. IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function[J]. J Exp Med, 2015, 212(4): 513-524. doi: 10.1084/jem.20141671
[29] Hausmann OV, Gentinetta T, Fux M, et al. Robust expression of CCR3 as a single basophil selection marker in flow cytometry[J]. Allergy, 2011, 66(1): 85-91. doi: 10.1111/j.1398-9995.2010.02431.x
-
计量
- 文章访问数: 1489
- PDF下载数: 500
- 施引文献: 0
下载: