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Abstract: Interleukin-33 that binds to the membrane receptor ST2L, can not only regulate mast cells, eosinophils, and group 2 innate lymphoid cells(ILC2s), but also affect the function of regulatory T cells(Treg) and Follicular helper T cells(Tfh). Interleukin-33 can activate the NF-κB and MAPK signaling pathways of the above cells, then participates in allergic immunity reaction. IL-33/ST2 signaling pathway is closely related to the allergic rhinitis(AR). IL-33 has been used as a new biomarker to evaluate the effect of AR treatment. At the same time, antagonizing IL-33 is also expected to become a new treatment. This article reviewed the latest research of IL-33/ST2 signaling pathway in the field of AR.
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Key words:
- rhinitis, allergic /
- Interleukin-33 /
- ST2 /
- signaling pathway
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