Changes of nasal nitric oxide in the treatment of allergic rhinitis with hydrogen-rich saline lavage of nasal cavity
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摘要: 目的 观察富氢盐水对鼻呼出一氧化氮(nNO)浓度的影响，探讨其治疗变应性鼻炎的可能机制。方法 临床筛选20例持续性中重度变应性鼻炎患者，先后用富氢生理盐水及生理盐水灌洗鼻腔，进行随机双盲自身对照研究，每周测试nNO值。结果 nNO值与变应性鼻炎的诊断及疗效有相关性，2种灌洗液治疗前后nNO值的差异有统计学意义(P < 0.01)。结论 富氢盐水灌洗鼻腔可以引起nNO的改变，有望用于变应性鼻炎的治疗。Abstract: Objective To observe the effect of hydrogen-rich saline on the concentration of nitric oxide in the nose, and to explore the mechanism of its treatment of allergic rhinitis.Method Twenty patients with moderate to severe persistent allergic rhinitis were enrolled in a randomized, double-blind, self-controlled study. The nasal cavity was lavaged with hydrogen-rich normal saline and normal saline, and the nasal nitric oxide(nNO) value was tested weekly.Result The test value of nNO was correlated with the diagnosis and curative effect of allergic rhinitis. The difference of nNO test values before and after treatment of the two lavage fluids was statistically significant(P < 0.01).Conclusion Hydrogen-rich saline lavage can cause nNO change in nasal cavity which may be used in the treatment of allergic rhinitis.
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Key words:
- rhinitis, allergic /
- nasal nitric oxide /
- normal saline /
- lavage nasal
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表 1 2种灌洗液治疗前后nNO值比较
灌洗液 例数 治疗前的nNO值 治疗后的nNO值 治疗前后nNO差值 A 20 608.95±129.36 366.45±106.86 242.50±179.90 B 20 601.20±123.48 503.25±94.49 97.95±89.58 P 0.847 0.000 0.002 
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表 2 2种灌洗液治疗中nNO值比较
灌洗液 例数 治疗前 第1周 第2周 第3周 第4周 A 20 608.95±129.36 694.40±100.25 560.55±83.83 455.20±65.70 366.45±106.86 B 20 601.20±123.48 568.75±116.62 549.60±109.88 513.65±102.37 503.25±94.49 P 0.847 0.001 0.725 0.038 0.000
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