Abstract: Objective:To investigate treatment effect of Sublingual immunotherapy of Dermatophagoides farinae drops in nasal cavity local allergy.Method:Selecting 60 patients as observation group, who had only nasal local allergy symptoms, allergen skin prick test and serum allergen specific IgE test were negative, but nasal secretions allergen specific IgE test and nasal mucous membrane excitation test were positive.Sublingual immunotherapy of Dermatophagoides farinae drops for three years were given to them.To detect symptom scores and VAS scores, eosinophilia counts in nasal secretion, nasal secretions allergen specific IgE test, nasal mucous membrane excitation test before treatment, after two years treatment, and three years treatment, The data of pre-therapy and posttherapy was taken for statistical analysis.Result:There was difference (P<0.05) in the symptom scores and VAS scores of patients in observation group before treatment and after two years treatment.There was difference (P<0.05) in the eosinophilia counts in nasal secretion of patients before treatment and after two years treatment.There was difference (P<0.05) in the nasal secretions allergen specific IgE test of patients before treatment and after two years treatment.There was difference (P<0.05) in the nasal mucous membrane excitation test of patients before treatment and after two years treatment.There was no difference (P>0.05) Symptom scores and VAS scores in the patients after two years treatment and after three years treatment. Conclusion:For patients with the typical medical history and symptoms of AR, but with allergen SPT and serum allergen SIgE test negative, there was local specific hypersensitivity in nasal mucosa, but there was not accompanied by systemic sensitization.Combined with nasal secretions allergen SIgE test or allergen nasal mucosa proocation tests positive, local allergic rhinitis can be diagnosed.Sublingual immunotherapy of Dermatophagoides farinae drops in nasal cavity local allergy was effective.