The correlation between children’s serum 25-hydroxyvitamin D and allergic rhinitis in Jiangxi Province
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摘要: 目的:研究江西省儿童血清25羟基维生素D[25(OH) D]水平与变应性鼻炎(AR)的相关性,为儿童AR的发病机制提供新的线索。方法:纳入来自江西省各县市的AR患儿76例和健康儿童68例,所有研究对象均进行问卷调查、过敏原皮肤点刺试验、血清特异性IgE检测、血清25(OH) D检测及血常规检查。AR患儿完成视觉模拟量表(VAS)评分和鼻结膜炎生存质量表(RQLQ)评分。结果:江西省AR患儿的平均BMI显著低于健康儿童(P<0.000 1),患儿的BMI与血清25(OH) D水平无相关性;AR患儿血清25(OH) D水平较健康儿童低(P=0.000 8),但受试者工作特征曲线下面积为0.661 4,即血清25(OH) D辅助诊断儿童AR的效率不高;患儿血清25(OH) D水平与AR的严重程度、性别、外周血嗜酸粒细胞及是否伴有哮喘均无相关性。结论:AR可影响患儿的生长发育;儿童血清25(OH) D缺乏与AR有相关性,但其辅助诊断AR的效率不高,不能作为临床诊断儿童AR的辅助指标。血清25(OH) D可能不直接参与AR的发病机制。Abstract: Objective:We attempt to investigate the correlation between serum 25-hydroxyvitamin D[25 (OH) D]level and allergic rhinitis (AR) of children in Jiangxi Province, for providing new clues for the pathogenesis of AR in children.Method:Seventy-six AR children and 68 healthy controls from various counties and cities of Jiangxi Province were enrolled.All subjects recepted questionnaire survey, allergen skin prick test, serum specific IgE test, serum 25 (OH) D test and routine blood test.AR children completed the visual analogue scale (VAS) scores and rhinoconjunctivitis quality of life questionnaire (RQLQ) scores.Result:The mean body mass index (BMI) of AR children in Jiangxi Province was significantly lower than that of healthy peers (P<0.000 1), but there was no correlation between BMI and serum 25 (OH) D level.Serum 25 (OH) D level of AR children was signtificantly lower, compared to the conrtols (P=0.000 8), while the area under the receiver operating characteristic curve (AUC) of subjects was 0.661 4, That is, serum 25 (OH) D was not an efficient auxiliary diagnosis in AR children.Serum 25 (OH) D level of AR children was not correlated with the severity, gender, peripheral blood eosinophils and asthma. Conclusion:AR can affect the growth and development of children.Children's serum 25 (OH) D deficiency was correlated to AR, but its efficiency for auxiliary diagnosis in AR is not high.So it cannot be used as an auxiliary indicator for clinical diagnosis of AR.Serum 25 (OH) D may not be directly involved in the pathogenesis of children's AR.
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Key words:
- rhinitis /
- allergic /
- 25-hydroxy vitamin D /
- children /
- body mass index /
- eosinophils
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