重度OSAHS患者综合治疗前后血清NGF、HO-1、IL-1β变化与认知功能的关系

苏亚; 张维; 冯晓辉; 李姣姣; 罗孟菲

doi:10.13201/j.issn.1001-1781.2018.20.008

重度OSAHS患者综合治疗前后血清NGF、HO-1、IL-1β变化与认知功能的关系

- 1. 湖南省人民医院耳鼻咽喉头颈外科(长沙, 410005);
- 2. 衡阳市第一人民医院耳鼻咽喉头颈外科;
- 3. 娄底市中心医院耳鼻咽喉头颈外科
基金项目:
湖南省教育厅课题 (No:16C0961)

详细信息

通讯作者: 冯晓辉, E-mail:Fengxiaohui8@aliyun.com

中图分类号: R563.8

收稿日期: 2018-05-02

The relationship between the changes of serum NGF,HO-1,IL-1 beta and cognitive function in patients with severe OSAHS after comprehensive treatment

- 1 Department of Otorhinolaryngology Head and Neck Surgery, Hunan Province People's Hospital, Changsha, 410005, China;
- 2 Department of Otorhinolaryngology Head and Neck Surgery, Hengyang First People's Hospital;
- 3 Department of Otorhinolaryngology Head and Neck Surgery, Loudi Central Hospital

More Information

Corresponding author: FENG Xiaohui, E-mail: Fengxiaohui8@aliyun.com

Received Date: 02 May 2018

摘要

摘要: 目的: 探究血清神经生长因子(NGF)、血红素氧化酶1(HO-1)、IL-1β与OSAHS患者认知功能之间的关系。方法: 测量60例重度OSAHS患者首次治疗前及治疗半年后的血清NGF、HO-1、IL-1β浓度以及蒙特利尔认知评分(MoCA)、AHI和LSaO₂。结果: ①重度OSAHS患者存在血清NGF下降及血清HO-1、IL-1β升高;②OSAHS患者AHI与NGF呈负相关(r=-0.648),与HO-1呈正相关(r=0.695),与IL-1β呈正相关(r=0.616);③MoCA值与NGF呈正相关(r=0.663),与HO-1呈负相关(r=-0.614),与IL-1β呈负相关(r=-0.346);④治疗半年后随访,AHI与血清HO-1、IL-1β较治疗前下降,MoCA值与血清NGF较治疗前上升,所有数据前后对比差异均有统计学意义(P<0.05)。结论: ①重度OSAHS患者存在认知功能损伤;②血清NGF、HO-1、IL-1β的变化可能与OSAHS患者认知功能改变有相关性;③综合治疗可以提高患者LSaO₂,降低AHI,对认知功能改善有一定作用;④通过规律监测血清NGF、HO-1、IL-1β浓度可能对于评估患者病情和愈后有一定的帮助。
- 神经生长因子 /
- 血红素氧化酶1 /
- 白介素1β /
- 认知功能 /
- 睡眠呼吸暂停低通气综合征 /
- 阻塞性
Abstract: Objective: To explore the relationship between the levels of serum nerve growth factor(NGF), hemeoxygenase 1(HO-1),interleukin-1 beta (IL-1β) and cognitive function in OSAHS patients.Method: the levels of serum NGF, HO-1 and IL-1β concentrations in 60 severe OSAHS patients were measured before and after treatment, and the Montreal cognitive score (MoCA), AHI and the LSaO₂ were also recorded.Result: ①OSAHS patients have serum NGF decreased and serum HO-1, IL-1β increased.②In severe OSAHS patients the AHI was negatively correlated with NGF (r=-0.648), positively correlated with HO-1 (r=0.695), and positively correlated with IL-1β(r=0.616).③The MoCA value was positively correlated with NGF (r=0.663), negatively correlated with HO-1 (r=-0.614), and negatively correlated with IL-1β(r=-0.346).④After half a year of follow-up, the AHI and Serum HO-1 and IL-1β were significantly decreased, while the MoCA values and serum NGF were significantly increased after treatment.Conclusion: ①Severe OSAHS patients have cognitive impairment.②The changes of serum NGF, HO-1 and IL-1β may be related to the changes of cognitive function in OSAHS patients. ③Comprehensive treatment can improve the patient's LSaO₂,reduce AHI, and improve the cognitive function.④Regular monitoring the concentration of serum NGF, HO-1, and IL-1β may be helpful to assess the patient's condition and recovery.
- nerve growth factor /
- hemeoxygenase 1 /
- interleukin-1beta /
- cognition function /
- sleep apnea hypopnea syndrome /
- obstructive

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