激素注射前后声带良性病嗓音变化的Meta分析

龙欢; 朱江

doi:10.13201/j.issn.1001-1781.2018.20.007

激素注射前后声带良性病嗓音变化的Meta分析

龙欢,
朱江^,

- 重庆医科大学附属第一医院耳鼻咽喉科(重庆, 400016)

详细信息

通讯作者: 朱江, E-mail:13668052903@163.com

中图分类号: R767.6

收稿日期: 2018-08-08

Meta-analysis of voice outcomes after steroid injection on benign vocal fold lesions

LONG Huan,
ZHU Jiang^,

- Department of Otolaryngology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China

More Information

Corresponding author: ZHU Jiang, E-mail: 13668052903@163.com

Received Date: 08 August 2018

摘要

摘要: 目的: 对声带类固醇激素注射(VFSI)治疗良性病变后的嗓音学变化进行Meta分析。方法: 使用相关关键词在PubMed、Embase、中国知网、万方数据库进行搜索,并用RevMan5.3软件对纳入文献的数据进行汇总分析(Meta分析)。采用随机效应模型,95%的置信区间,使用I²值、P值评估其异质性;在Z统计中,使用P值评估其是否有统计学意义。结果: 共纳入7篇文献共344个病例,Meta分析结果显示最长发声时间(MPT)、基频微扰(Jitter)在激素注射前后具有统计学意义,注射后MPT增大、Jitter减小;嗓音障碍指数、振幅微扰在激素注射前后无统计学意义。结论: VFSI治疗声带良性病变在嗓音学变化上有优势。由于文献较少,默认存在发表偏倚,希望有更长随访周期的文献能提供更准确的长期疗效对比结果。
- 声带良性病变 /
- 激素类 /
- 嗓音 /
- Meta分析
Abstract: Objective: The aim of this study is to perform a meta-analysis of vocal changes after vocal cord steroid injection (VFSI) in the treatment of benign lesions.Method: Pubmed, Embase, CNKI and Wanfang database were searched using the keywords. A total of 7 articles were characterized based on our keyword search. The chi-square-based I² statistic test was employed to assess the between-study heterogeneity. Additionally, random effects models were used to calculate mean differences with 95% confidence intervals.Result: A total of 344 cases were included in 7 literatures. Meta-analysis demonstrated a significant increase in maximal phonation time(MPT) and decrease Jitter after VFSI.The index and amplitude perturbations were not statistically significant before and after hormone injection.Conclusion: Our results support that VFSI has advantages in terms of voice quality. However, we need more studies with longer follow-up periods to validate our findings.
- benign vocal fold lesions /
- hormones /
- voice outcomes /
- Meta-analysis

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