腺样体肥大在儿童分泌性中耳炎发病机制中的作用研究进展

陈文欣; 付勇

doi:10.13201/j.issn.1001-1781.2018.17.017

腺样体肥大在儿童分泌性中耳炎发病机制中的作用研究进展

陈文欣,
付勇^,

- 浙江大学医学院附属儿童医院耳鼻咽喉科(杭州, 310052)
基金项目:
国家自然科学基金面上项目（No：81470686）；浙江省自然科学基金（No：LY14H130001）；浙江省医药卫生科学研究基金计划（No：2014KYB077）

详细信息

通讯作者: 付勇,E-mail:1307022@zju.edu.cn

中图分类号: R764.21

收稿日期: 2018-04-12

Advances in the role of adenoid hypertrophy in the pathogenesis of otitis media with effusion in children

CHEN Wenxin,
FU Yong^,

More Information

Corresponding author: FU Yong, E-mail: 1307022@zju.edu.cn

Received Date: 12 April 2018

摘要

- 分泌性中耳炎 /
- 腺样体肥大 /
- 发病机制
Abstract: Adenoid hypertrophy (AH) and otitis media with effusion (OME) are both common diseases in pediatric otorhinolaryngology and are often associated with each other. Children are often diagnosed with otitis media with effusion and adenoid hypertrophy (OME/AH). Adenoids are immune lymphoid tissues of children's upper respiratory tract, and are important barriers against upper respiratory tract infections. During an upper respiratory tract infection, bacteria or viruses repeatedly stimulate immune lymphoid tissue to cause hyperplasia, and pathological hypertrophy is often accompanied by OME and other related symptoms. In recurrent or chronic OME, hyperproliferative adenoids are usually excised indicating that the two diseases may have a certain correlation. Recently, more and more studies have shown that AH plays an important role in the pathogenesis of OME in children. This article elucidates the role of AH in the pathogenesis of childhood OME from adenoid mechanical obstruction, adenoid bacterial and bacterial biofilm, adenoid local immune regulation, and IgE-mediated allergic reaction.
- otitis media with effusion /
- adenoid hypertrophy /
- pathogenesis

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