局部变应性鼻炎概述

胡秋蓉; 李靖

doi:10.13201/j.issn.1001-1781.2018.17.018

局部变应性鼻炎概述

胡秋蓉,
李靖^,

- 广州医科大学附属第一医院过敏与临床免疫科广州呼吸健康研究院呼吸疾病国家重点实验室
基金项目:
国家自然科学基金面上项目（No：81370129）

详细信息

通讯作者: 李靖,E-mail:lijing@gird.cn

中图分类号: R765.21

收稿日期: 2018-03-03

A brief introduction of local allergic rhinitis

HU Qiurong,
LI Jing^,

More Information

Corresponding author: LI Jing, E-mail: lijing@gird.cn

Received Date: 03 March 2018

摘要

- 局部变应性鼻炎 /
- 免疫球蛋白E /
- 变应原鼻激发试验 /
- 发病机制 /
- 免疫治疗
Abstract: Local allergic rhinitis (local allergic rhinitis, LAR) is a newly proposed concept in recent years. It refers to patients with typical allergic rhinitis symptoms but skin prick test (SPT) and serum specificity IgE are negative, while nasal mucosa can produce local specific IgE and allergen provocation test (NAPT) are positive. The rate of clinical misdiagnose is high. The diagnosis mainly relies on typical nasal symptoms, positive NAPT and/or detection of local specific IgE. It needs to be distinguished from allergic rhinitis (AR) and non-allergic rhinitis (NAR). The main mechanism of its onset is the Th2-type allergic inflammatory response mediated by locally produced IgE. Eosinophils and mast cells are also involved in the inflammatory process. The current study considers LAR to be a separate disease from AR. Allergen immunotherapy (AIT) can be used to treat the disease.
- local allergic rhinitis /
- immunoglobulin E /
- allergen nasal provocation test /
- pathogenesis /
- immunotherapy

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