干冷空气对鼻黏膜的影响

黄嫣然; 娄鸿飞; 张罗

doi:10.13201/j.issn.1001-1781.2018.01.015

干冷空气对鼻黏膜的影响

- 1. 首都医科大学附属北京同仁医院耳鼻咽喉头颈外科(北京, 100730);
- 2. 鼻病研究北京市重点实验室北京市耳鼻咽喉科研究所;
- 3. 首都医科大学附属北京同仁医院过敏科
基金项目:
科技部国家重点研发计划（No：2016YFC20160905200）；教育部创新团队发展计划（No：IRT13082）；国家自然科学基金重点项目（No：81630023）；国家自然科学基金重点国际合作研究项目（No：81420108009）和国家自然科学基金青年基金项目（No：81400444）

详细信息

通讯作者: 张罗,E-mail:dr.luozhang@139.com

中图分类号: R765

收稿日期: 2017-08-30

The influence of cold dry air on nasal mucosa

More Information

Corresponding author: ZHANG Luo, E-mail: dr.luozhang@139.com

Received Date: 30 August 2017

摘要

- 干冷空气 /
- 非变应性鼻炎 /
- 非特异性鼻高反应性 /
- 瞬时受体电位
Abstract: Nonspecific nasal hyperreactivity (NHR) has been widespread observed in patients with allergic rhinitis (AR) and nonallergic rhinitis (NAR). As a clinical hallmark, NHR is more common in patients with NAR. The cold dry air (CDA) can stimulate nasal symptoms such as rhinorrhea and nasal obstruction, and the CDA provocation test can be used as a reliable objective method to evaluate NHR. The mechanism of CDA-induced nasal symptoms is very complicated and thus it has not yet been fully illuminated. The innervation of the nasal nerves includes sensory nerve (trigeminal ganglion), sympathetic nerve (superior cervical ganglion) and parasympathetic nerve (sphenopalatine ganglion). CDA innervation may also be associated with these nerves and associated signal pathway. Recently, general attention has been focused on the transient receptor potential (TRP) channel, including TRP vanilloid-1 (TRPV1) and TRP ankyrin-1 (TRPA1). More relevant researches are needed to further clarify the mechanism.
- cold dry air /
- nonallergic rhinitis /
- nonspecific nasal hyperreactivity /
- TRP vanilloid-1

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