头颈部黏膜恶性黑色素瘤淋巴结转移相关因素分析

尹高菲; 郭伟; 陈晓红; 黄志刚

doi:10.13201/j.issn.1001-1781.2017.23.002

头颈部黏膜恶性黑色素瘤淋巴结转移相关因素分析

- 首都医科大学附属北京同仁医院耳鼻咽喉头颈外科(北京, 100005)
基金项目:
国家自然科学基金 (No:81670946)

北京市医管局临床医学发展专项扬帆计划 (No:XMLX201507)

北京市属医院科研培育计划 (No:PX2017032)

详细信息

通讯作者: 陈晓红, E-mail:trchxh@163.com

中图分类号: R739.91

收稿日期: 2017-06-25

The related factors of head and neck mocosal melanoma with lymph node metastasis

- Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, 100005, China

More Information

Corresponding author: CHEN Xiaohong, E-mail: trchxh@163.com

Received Date: 25 June 2017

摘要

摘要: 目的: 探讨头颈部黏膜恶性黑色素瘤伴淋巴结转移的相关因素,为疾病的早期及进一步诊治提供帮助。方法: 回顾性分析行手术治疗的117例头颈部黏膜恶性黑色素瘤患者,其中11例患者术后病理证实存在淋巴结转移,按1:3随机选择术后病理证实未出现淋巴结转移的33例患者的临床资料,对头颈部黏膜恶性黑色素瘤患者出现淋巴结转移的可能相关因素进行统计学分析,主要涉及患者年龄、性别、是否为复发、是否存在骨质侵袭、病变原发位置等因素,采用单因素及Logistic回归分析,以P<0.05为差异有统计学意义。结果: 头颈部黏膜恶性黑色素瘤淋巴结转移率为9.40%(11/117),单因素分析筛选出复发(P=0.000)、骨质侵袭(P=0.001)以及原发位置(P=0.007)这3个因素与淋巴结转移相关。经Logistic回归分析,确定复发(P=0.021)为淋巴结转移的危险因素,骨质侵袭(P=0.487)和原发位置(P=0.367)的影响有待进一步探究。结论: 头颈部黏膜恶性黑色素瘤复发的患者通常伴有淋巴结转移,对于复发的患者要格外重视淋巴结检查及合理的治疗方式的选择。
- 头颈部肿瘤 /
- 黑色素瘤 /
- 淋巴结转移
Abstract: Objective: To investigate the related factors of mucosal melanoma of head and neck with lymph node metastasis for early diagnosis and further treatments.Method: A retrospective analysis of 117 cases of head and neck mucosal malignant melanoma patients which received surgical treatment was performed. Eleven cases of patients with pathologically confirmed lymph node metastasis and 33 cases without lymph node metastasis (1:3) were randomly selected to analyze. The related factors of lymph node metastasis of head and neck mucosal melanoma patients including age, gender, whether the existence of recurrence, bone invasion, lesion location were analyzed. The single factor and logistic regression analysis were performed, P<0.05 difference was statistically significant.Result: The lymph node metastasis rate of head and neck mucosal melanoma was 9.40% (11/117), the single factor analysis showed that there were 3 factors to be associated with lymph node metastasis, which was recurrence (P=0.0000), bone invasion (P=0.001), primary position (P=0.007). Recurrence (P=0.021) was a risk factor for lymph node metastasis according to the Logistic regression analysis, and the impact of bone invasion (P=0.487) and primary location (P=0.367) remained to be further explored.Conclusion: The patients of head and neck mucosal melanoma with the presence of recurrent usually accompanied by a further progression of the disease, such as lymph node metastasis, so for recurrent patients should pay special attention to the situation of lymph node and choose the reasonable treatment.
- head and neck neoplasms /
- melanoma /
- lymph metastasis

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