头颈肿瘤多组学研究进展

王斌全, 高伟, 吴勇延. 头颈肿瘤多组学研究进展[J]. 临床耳鼻咽喉头颈外科杂志, 2017, 31(23): 1785-1788+1792. doi: 10.13201/j.issn.1001-1781.2017.23.001
引用本文: 王斌全, 高伟, 吴勇延. 头颈肿瘤多组学研究进展[J]. 临床耳鼻咽喉头颈外科杂志, 2017, 31(23): 1785-1788+1792. doi: 10.13201/j.issn.1001-1781.2017.23.001
WANG Binquan, GAO Wei, WU Yongyan. Progress in multi-omic study of head and neck cancer[J]. J Clin Otorhinolaryngol Head Neck Surg, 2017, 31(23): 1785-1788+1792. doi: 10.13201/j.issn.1001-1781.2017.23.001
Citation: WANG Binquan, GAO Wei, WU Yongyan. Progress in multi-omic study of head and neck cancer[J]. J Clin Otorhinolaryngol Head Neck Surg, 2017, 31(23): 1785-1788+1792. doi: 10.13201/j.issn.1001-1781.2017.23.001

头颈肿瘤多组学研究进展

  • 基金项目:

    山西省头颈部恶性肿瘤精准诊疗重点科技创新平台专项 (No:201605D151003)

    山西省科技成果转化引导专项 (No:201604D131002)

详细信息
    作者简介:

    王斌全, E-mail:wbq_xy@sxent.org, 1960年生, 教授、主任医师, 博士生导师, 博士后合作导师, 高等学校教学名师, 中央及省委联系的高级专家, 国家卫生系统突出贡献人才, 享受国务院特殊津贴专家, 国家级教学团队负责人, 致力于头颈肿瘤基础与临床研究。1997-1999年曾分别在德国洪堡大学及美国加州大学进行高级访问学者研究。现任山西医科大学第一医院院长、党委副书记、耳鼻咽喉头颈外科主任, 耳鼻咽喉头颈肿瘤山西省重点实验室主任, 山西医科大学耳鼻咽喉研究所所长, 山西省头颈部恶性肿瘤精准诊疗重点科技平台负责人, 耳鼻咽喉头颈肿瘤综合治疗山西省科技创新重点团队带头人。2013年被确定为山西省高端创新人才培养引进工程“院士后备人选”, 山西省高校“131领军人才工程知名学者”。学术任职主要包括中华医学会耳鼻咽喉头颈外科学分会山西省分会主任委员, 中华医学会健康管理学分会常委, 中华抗癌协会头颈肿瘤专业常委, 中国医疗保健国际交流促进会耳鼻咽喉外科分会第一届委员会常委, 第五届中国残疾人康复协会无喉者康复专业委员会副主任委员, 中国医院协会人力资源管理专业委员会常委, 山西省医师协会耳鼻喉分会会长, 山西省医师协会内镜医师分会耳鼻咽喉专业委员会主委等。主持完成的教学成果获得国家教学成果二等奖1项、省级教学成果一等奖5项;担任全国规划教材《耳鼻咽喉科学》 (八年制及七年制) 教材副主编, 三年制《眼耳鼻喉口腔科学》教材主编, 主持再版两次的《耳鼻咽喉-头颈应用解剖学》成为临床医师学习参考的专科书籍。完成科技论文260余篇, SCI收录19篇, 获中华医学奖二等奖1项, 省科技进步一等奖5项, 二等奖7项, 获得专利发明授权16项。完成国家自然科学基金项目3项, 在研1项, 同时承担省部级科研项目15项

    通讯作者: 王斌全, E-mail:wbq_xy@sxent.org
  • 中图分类号: R739.91

Progress in multi-omic study of head and neck cancer

More Information
  • 加载中
  • [1]

    SIEGEL R L, MILLER K D, JEMAL A.Cancer statistics, 2016[J].CA Cancer J Clin, 2016, 66:7-30.

    [2]

    CHEN W, ZHENG R, BAADE P D, et al.Cancer statistics in China, 2015[J].CA Cancer J Clin, 2016, 66:115-132.

    [3]

    SIEGEL R, WARD E, BRAWLEY O, et al.Cancer statistics, 2011:the impact of eliminating socioeconomic and racial disparities on premature cancer deaths[J].CA Cancer J Clin, 2011, 61:212-236.

    [4]

    LI H, WAWROSE J S, GOODING W E, et al.Genomic analysis of head and neck squamous cell carcinoma cell lines and human tumors:a rational approach to preclinical model selection[J].Mol Cancer Res, 2014, 12:571-582.

    [5]

    ALEXANDROV L B, NIK-ZAINAL S, WEDGE D C, et al.Signatures of mutational processes in human cancer[J].Nature, 2013, 500:415-421.

    [6]

    CANCER GENOME ATLAS NETWORK.Comprehensive genomic characterization of head and neck squamous cell carcinomas[J].Nature, 2015, 517:576-582.

    [7]

    SEIWERT T Y, ZUO Z, KECK M K, et al.Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas[J].Clin Cancer Res, 2015, 21:632-641.

    [8]

    HENDERSON S, CHAKRAVARTHY A, SU X, et al.APOBEC-mediated cytosine deamination links PIK3CA helical domain mutations to human papillomavirus-driven tumor development[J].Cell Rep, 2014, 7:1833-1841.

    [9]

    SUÁREZ E, GONZÁLEZ L, PÉREZ-MITCHELL C, et al.Pathway Analysis using Gene-expression Profiles of HPV-positive and HPV-negative Oropharyngeal Cancer Patients in a Hispanic Population:Methodological Procedures[J].P R Health Sci J, 2016, 35:3-8.

    [10]

    ZOU A E, ZHENG H, SAAD M A, et al.The noncoding landscape of head and neck squamous cell carcinoma[J].Oncotarget, 2016, 7:51211-51222.

    [11]

    YAN L, ZHAN C, WU J, et al.Expression profile analysis of head and neck squamous cell carcinomas using data from The Cancer Genome Atlas[J].Mol Med Rep, 2016, 13:4259-4265.

    [12]

    MENG L Z, FANG J G, SUN J W, et al.Aberrant Expression Profile of Long Noncoding RNA in Human Sinonasal Squamous Cell Carcinoma by Microarray Analysis[J].Biomed Res Int, 2016, 2016:1095710.

    [13]

    GAO W, ZHANG C, MA T, et al.Potential biomarkers and their regulatory relationships in laryngeal squamous cell carcinoma with lymph node metastasis revealed by integrating mRNA, microRNA and long non-coding RNA profiles[J].Int J Clin Exp Pathol, 2016, 9:5103-5116.

    [14]

    HE Q, TIAN L, JIANG H, et al.Identification of laryngeal cancer prognostic biomarkers using an inflammatory gene-related, competitive endogenous RNA network[J].Oncotarget, 2017, 8:9525-9534.

    [15]

    DESCAMPS G, WATTIEZ R, SAUSSEZ S.Proteomic study of HPV-positive head and neck cancers:preliminary results[J].Biomed Res Int, 2014, 2014:430906.

    [16]

    GUERRERA I C, QUETIER I, FETOUCHI R, et al.Regulation of interleukin-6in headand neck squamous cell carcinoma is related to papillomavirus infection[J].J Proteome Res, 2014, 13:1002-1011.

    [17]

    SLEBOS R J, JEHMLICH N, BROWN B, et al.Proteomic analysis of oropharyngeal carcinomas reveals novel HPV-associated biological pathways[J].Int J Cancer, 2013, 132:568-579.

    [18]

    LO W Y, LAI C C, HUA C H, et al.S100A8 is identified as a biomarker of HPV18-infected oral squamous cell carcinomas by suppression subtraction hybridization, clinical proteomics analysis, and immunohistochemistry staining[J].J Proteome Res, 2007, 6:2143-2151.

    [19]

    KAMARAJAN P, RAJENDIRAN T M, KINCHEN J, et al.Head and Neck Squamous Cell Carcinoma Metabolism Draws on Glutaminolysis, and Stemness Is Specifically Regulated by Glutaminolysis via Aldehyde Dehydrogenase[J].J Proteome Res, 2017, 16:1315-1326.

    [20]

    MUKHERJEE P K, FUNCHAIN P, RETUERTO M, et al.Metabolomic analysis identifies differentially produced oral metabolites, including the oncometabolite 2-hydroxyglutarate, in patients with head and neck squamous cell carcinoma[J].BBA Clin, 2017, 7:8-15.

    [21]

    OHSHIMA M, SUGAHARA K, KASAHARA K, et al.Metabolomic analysis of the saliva of Japanese patients with oral squamous cell carcinoma[J].Oncol Rep, 2017, 37:2727-2734.

    [22]

    SKINNER H D, GIRI U, YANG L, et al.Proteomic Profiling Identifies PTK2/FAK as a Driver of Radioresistance in HPV-negative Head and Neck Cancer[J].Clin Cancer Res, 2016, 22:4643-4650.

    [23]

    ZHANG W, EDWARDS A, FANG Z, et al.Integrative Genomics and Transcriptomics Analysis Reveals Potential Mechanisms for Favorable Prognosis of Patients with HPV-Positive Head and Neck Carcinomas[J].Sci Rep, 2016, 6:24927.

    [24]

    CHANDRANI P, UPADHYAY P, IYER P, et al.Integrated genomics approach to identify biologically relevant alterations in fewer samples[J].BMC Genomics, 2015, 16:936-936.

    [25]

    MARTIN D, ABBA M C, MOLINOLO A A, et al.The head and neck cancer cell oncogenome:aplatform for the development of precision molecular therapies[J].Oncotarget, 2014, 5:8906-8923.

  • 加载中
计量
  • 文章访问数:  157
  • PDF下载数:  209
  • 施引文献:  0
出版历程
收稿日期:  2017-11-16

目录