Clinical observation of saccharomyces boulardii combined with cetirizine hydrochloride in children allergic rhinitis
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摘要: 目的: 探讨布拉氏酵母菌联合盐酸左西替利嗪治疗小儿变应性鼻炎(AR)的临床疗效及对血清干扰素-γ(IFN-γ)和IL-4水平的影响。方法: 90例患儿随机分为观察组与对照组,每组45例, 对照组用盐酸左西替利嗪滴剂(2~6岁,5 ml/次;>6岁,10 ml/次;1次/d,口服)。观察组在对照组基础上联合布拉氏酵母菌(<3岁,0.25 g/次,1次/d;>3岁,0.25 g/次,2次/d,口服)。4周为1个疗程,并设30例为健康组。结果: 2组治疗前血清IFN-γ水平明显低于健康组(P<0.01),而IL-4水平明显高于健康组(P<0.01);治疗后2组均有不同程度的上调IFN-γ及下调IL-4的水平,但以治疗组的作用更明显(P<0.01)。观察组临床总有效率为91.11%,明显高于对照组的68.89%(χ2=6.94,P<0.01)。治疗后,2组患儿各项症状积分均较治疗前降低,但观察组明显低于对照组(P<0.01)。治疗后组间比较,观察组明显优于对照组(P<0.01)。结论: 布拉氏酵母菌联合盐酸左西替利嗪口服溶液治疗小儿AR有明显的临床疗效,其作用机制可能与纠正紊乱的IFN-γ与IL-4有关。Abstract: Objective: To study the treatment efficacy of Saccharomyces boulardii combined with Cetirizine Hydrochloride of children with allergic rhinitis (AR) and the influence of IFN-γ and interleukin-4 (IL-4) Level in serum.Method: Ninty cases of children were randomly divided into observation group and control group (both n=45).The control group with levocetirizine hydrochloride drops, 5 mL/time for 2-6 years old, 10 mL/time for >6 years old, qd oral. Group based on the combination of Saccharomyces boulardi, 0.25 g/time for <3 years old, qd, >3 years old, 0.25 g, bid. Four weeks for a course of treatment, and set 30 cases for the health group.Result: The level of serum IFN-γ was significantly lower in the two groups than in the healthy group (P<0.01), while the level of IL-4 was significantly higher than that of the healthy group (P<0.01). After treatment, the levels of IFN-γ of both groups were up-regulated And the level of IL-4 were down-regulated, but the effect of the treatment group was more obvious (P<0.01). The total effective rate was 91.11% in the observation group, which was significantly higher than that in the control group (68.89%, χ2=6.94, P<0.01). After treatment, the symptom scores of the two groups were lower than those before treatment, but the observation group was significantly lower than the control group (P<0.01). Compared with the control group, the observation group was significantly better than the control group (P<0.01).Conclusion: The combination of Saccharomyces boulardi and levocetirine hydrochloride in the treatment of children with AR has obvious clinical efficacy, and its mechanism may be related to the correction of interferon IFN-γ and IL-4.
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Key words:
- saccharomyces boulardi /
- levocetirizine hydrochloride /
- rhinitis /
- allergic /
- cytokines /
- children
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