先天性聋患儿人工耳蜗植入后大脑皮层活动演变与康复效果研究

王籼君; 梁茂金; 张军鹏; 黄华; 郑亿庆

doi:10.13201/j.issn.1001-1781.2017.21.003

先天性聋患儿人工耳蜗植入后大脑皮层活动演变与康复效果研究

- 1 四川大学电气信息学院医学信息工程(成都, 610065);
- 2 中山大学孙逸仙纪念医院耳鼻咽喉科

详细信息

通讯作者: 郑亿庆, E-mail:yiqingzheng@hotmail.com

中图分类号: R318.18

收稿日期: 2017-07-13

Research on activity evolution of cerebral cortex and hearing rehabilitation of congenitally deaf children after cochlear implant

- 1 Department of Medical Information Engineering, School of Electrical Engineering and Information, Sichuan University, Chengdu, 610065, China;
- 2 Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University

More Information

Corresponding author: ZHENG Yiqing, E-mail: yiqingzheng@hotmail.com

Received Date: 13 July 2017

摘要

摘要: 目的: 针对先天性聋患儿群体在人工耳蜗植入(CI)后听觉功能恢复效果存在较大差异的问题,从诱发脑电源活动角度探讨影响患儿CI术后听觉功能恢复效果的内在机制。方法: 首先征集先天性聋患儿23例以及正常对照儿童10例,于术前(0个月)及术后3、6、9和12个月定期采集视觉诱发的事件相关电位(ERP)数据,在CI术后12个月依据听觉功能恢复评估情况,将患儿划分为恢复"良好"与"较差"组。然后采用标准低分辨率层析成像(sLORETA)源定位分析技术,呈现出2组患儿相关大脑皮层的ERP演化情况,同时与正常对照组相比较。结果: 先天性聋患儿耳聋期间存在大脑皮层跨模态功能重组;在CI术后患儿大脑皮层跨模态功能重组逐渐退化,相关脑区活动随之趋于正常,在术后第12个月听觉功能恢复"良好"与"较差"组患者在颞叶和顶叶周边联合皮层活动差异有统计学意义(P<0.05)。结论: 先天性聋患儿大脑皮层跨模态重组的正常化逆转与CI术后患儿听觉功能的恢复情况相关,特别是患儿颞叶和顶叶周边视听联合皮层的异常活动的正常化在一定程度上影响了听觉功能的恢复效果,对指导患者CI术后听力恢复训练和康复评估具有重要意义。
- 聋 /
- 先天性 /
- 人工耳蜗植入 /
- 源定位 /
- 大脑皮层跨模态功能重组 /
- 康复效果
Abstract: Objective: There is a significant difference in the hearing rehabilitation between the congenitally deaf children after cochlear implant(CI). The intrinsic mechanism that affects the hearing rehabilitation in patients was discussed from the perspective of evoked EEG source activity.Method: Firstly, we collected the ERP data from 23 patients and 10 control group children during 0, 3, 6, 9 and 12 months after CI. According to the hearing rehabilitation during 12months after CI, the patients were divided into two groups:rehabilitation of "the good" and "the poor". Then we used sLORETA to show the changes in the groups of patients' cerebral cortex and compared with the control group.Result: Cross-modal reorganization of cerebral cortex exists in the congenitally deaf children. The cross-modal reorganization gradually degraded and the activity of the relevant cortex followed by normally after CI. There was a statistically significant difference(P<0.05) in the temporal lobe and the associated cortex around parietal lobe between "the good" and "the poor" groups after 12 months.Conclusion: The normalization of the cross-modal reorganization in patients reflects the hearing rehabilitation after CI, especially the normalization of the activity of the temporal lobe and the associated cortex around parietal lobe, which influences the rehabilitation effect of the auditory function to some extent. This research demonstrated the detection of the mechanism has important significance for the hearing recovery training and evaluation of the hearing rehabilitation after CI.
- hearing loss /
- congenitally /
- cochlear implant /
- source localization /
- cross-modal reorganization /
- rehabilitation effect

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