局部晚期下咽癌的治疗进展

耿志洋; 郑宏良

doi:10.13201/j.issn.1001-1781.2017.09.024

局部晚期下咽癌的治疗进展

耿志洋,
郑宏良^,

- 第二军医大学附属长海医院耳鼻咽喉头颈外科(上海, 200433)

详细信息

通讯作者: 郑宏良,E-mail:zheng_hl2004@163.com

中图分类号: R739.6

收稿日期: 2017-02-10

Advances in treatment of locally advanced hypopharyngeal cancer

GENG Zhiyang,
ZHENG Hongliang^,

More Information

Corresponding author: ZHENG Hongliang, E-mail: zheng_hl2004@163.com

Received Date: 10 February 2017

摘要

- 下咽肿瘤 /
- 手术 /
- 诱导化学治疗
Abstract: Hypopharyngeal cancer is a common malignant tumor of otorhinolaryngology,which is considered to be one of the head and neck tumor with poor prognosis.Hypopharyngeal cancer is insidious in its onset and progresses rapidly,leading to significant delay in diagnosis;Most patients are in late stage at diagnosis.Surgery combined with chemoradiotherapy is the main treatment of locally advanced hypopharyngeal cancer.Biological treatment has drawn more and more attentions.In this paper,we summarize the progress in the treatment of locally advanced hypopharyngeal cancer.
- hypopharyngeal cancer /
- surgery /
- induction chemotherapy

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参考文献(42)

[1]	COOPER J S,PORTER K,MALLIN K,et al. National Cancer Database reporton cancer of the head and neck:10-year update[J].Head Neck,2009,31:748-758.
[2]	GOURIN C G,TERRIS D J. Carcinoma of the hypopharynx[J]. Surg Oncol Clin N Am, 2004,13:81-98.
[3]	BUCKLEY J G,MACLENNAN K. Cervical node metastases in laryngeal and hypopharyngeal cancer:a prospective analysis of prevalence and distribution[J]. Head Neck, 2000, 22:380-385.
[4]	HUANG Y C.Regular screening of esophageal cancer for 248 newly diagnosed hypopharyngeal squamous cell carcinoma by unsedated transnasal esophagogastroduodenoscopy[J]. Oral Oncol,2016,55:55-60.
[5]	TAKES R P,STROJAN P,SILVER C E,et al.Current trends in initial management of hypopharyngeal cancer:the declining use of open surgery[J]. Head Neck,2012,34:270-281.
[6]	SATO K,KUBOTA A,FURUKAWA M,et al.Definitive radiotherapy for early stage hypopharyngeal squamous cell carcinoma[J]. Eur Arch Otorhinolaryngol,2015,272:2001-2006.
[7]	YOSHIMURA R,KAGAMI Y,ITO Y,et al.Outcomes in patients with early-stage hypopharyngeal cancer treated with radiotherapy[J].Int J Radiat Oncol Biol Phys, 2010.77:1017-1023.
[8]	PESKO P, SABLJAK P,BJELOVIC M,et al.Surgical treatment and clinical course of patients with hypopharyngeal carcinoma[J].Dis Esophagus, 2006,20:248-253.
[9]	CHANG M F T,WANG H M,KANG C J,et al.Treatment results for hypopharyngeal cancer by different treatment strategies and its secondary primary-an experience in Taiwan[J]. Radia Oncol,2010,5:91-97.
[10]	董频,英信江,陈歆维,等.新辅助化疗方案尼妥珠单抗联合奈达铂和5-氟尿嘧啶治疗下咽鳞癌初步临床分析[J].山东大学耳鼻喉眼学报,2016,30(1):10-14.
[11]	JIANG Y,MENG N,WANG J,et al.CT-guided iodine-125 seed permanent implantation for recurrent head and neck cancers[J].Radiation Oncol,2010,5:68-75.
[12]	LI L, JIE Y,LI X J,et al.(125)I Seed permanent implantation as a palliative treatment for stage Ⅲ and Ⅳ hypopharyngeal carcinoma[J]. Clin Exp Otorhinolaryngol, 2016,9:185-191.
[13]	MIAH A B,BHIDE S A,GUERRERO-URBANO M T,et al.Dose-escalated intensity-modulated radiotherapy is feasible and may improve locoregional control and laryngeal preservation in laryngo-hypopharyngeal cancers[J].Int J Radiat Oncol Biol Phys,2012,82:539-547.
[14]	GUJRAL D M, MIAH A B,BODLA S,et al. Final long-term results of a phase Ⅰ/Ⅱ study of dose-escalated intensity-modulated radiotherapy for locally advanced laryngo-hypopharyngeal cancers[J].Oral Oncol,2014,50:1089-1097.
[15]	孔琳,陆嘉德.头颈部恶性肿瘤的质子、重离子治疗实践[J].中华放射肿瘤学杂志, 2016, 25(5):427-431.
[16]	JAKOBI A,BANDURSKA-LUQUE A,STTITZER K,et al.Identification of patient benefit from proton therapy for advanced head and neck cancer patients based on individual and subgroup normal tissue complication probability analysis[J].Int J Radiat Oncol Biol Phys, 2015,92:1165-1174.
[17]	VAN DER LAAN H P,VAN DE WATER T A,VAN HERPT H E,et al.The potential of intensity-modulated proton radiotherapy to reduce swallowing dysfunction in the treatment of head and neck cancer:a planning comparative study[J].Acta Oncol,2013,52:561-569.
[18]	HANNA G J, HADDAD R I, LORCH J H, et al. Induction chemotherapy for locoregionally advanced head and neck cancer:past,present,future[J]. Oncol, 2013, 18:288-293.
[19]	JANORAY G,POINTREAU Y,GARAUD P,et al.Long-Term results of a multicenter randomized phase Ⅲ trial of induction chemotherapy with cisplatin, 5-fluorouracil, docetaxel for larynx preservation[J]. J Natl Cancer,2015,108:.
[20]	LORCH J H,GOLOUBEVA O,HADDAD R I,et al. Induction chemotherapy with cisplatin and fluorouracil alone or in combination with docetaxel in locally advanced squamous-cell cancer of the head and neck:long-term results of the TAX 324 randomised phase 3 trial[J]. Lancet Oncol, 2011,12:153-159.
[21]	MESA R,VZQUEZ S,GRAU J J,et al. A phase 2 open label, single-arm trial to evaluate the combination of cetuximab plus taxotere, cisplatin, and 5-Flurouracil as an induction regimen in patients with unresectable squamous cell carcinoma of the head[J]. Int J Radiat Oncol Biol Phys,2016,94:289-296.
[22]	SU X,HE C,TANG T,et al.Sequential four-drug chemotherapy and intensity-modulated radiotherapy for larynx preservation in resectable advanced larynx and hypopharynx cancer:a pilot study[J]. Am J Otolaryngol,2017,38:52-56.
[23]	BONNER J A, HARARI P M, GIRALT J, et al. Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer:5-year survival data from a phase 3 randomized trial, and relation between cetuximab-induced rash and survival[J]. Lancet Oncol, 2010,11:21-28.
[24]	VERMORKEN J B,MESIA R,RIVERA F,et al.Platinum-based chemotherapy plus cetuximab in head and neck cancer[J].N Engl J Med,2008,359:1116-1127.
[25]	张欣欣,王嘉陵,武文明,等.非手术综合治疗保留中晚期下咽癌患者喉器官的临床研究[J].中华耳鼻咽喉头颈外科杂志,2014,49(7):558-563.
[26]	郑宏良,朱敏辉.保留喉功能的下咽癌手术[J].中国眼耳鼻喉杂志,2012,12(5):277-280.
[27]	周梁.喉癌、下咽癌功能保全性治疗进展[J].中国癌症杂志,2013,23(12):942-948.
[28]	URBA S G,MOON J,GIRL P G,et al.Organ preservation for advanced resectable cancer of the base of tongue and hypopharynx:a southwest oncology group trial[J].J Clin Oncol,2005,23:88-95.
[29]	张彬,邬振华,余济春,等.T3和T4期梨状窝癌喉功能保留及游离皮瓣修复术[J].中华耳鼻咽喉头颈外科杂志,2013,48(11):919-923.
[30]	JIN T,LI X Z,LEI D P,et al.Preservation of laryngeal function improves outcomes of patients with hypopharyngeal carcinoma[J]. Eur Arch Otorhinolaryngol,2015,272:1785-1791.
[31]	SCHMITZ S,MACHIELS J P,WEYNAND B, et al.Results of selective neck dissection in primary management of head and neck squamous cell carcinoma[J].Eur Arch Otorhinolaryngol,2009,266:437-443.
[32]	KATILMI H.Is dissection of levels 4 and 5 justified for cN0 laryngeal and hypopharyngeal cancer[J]? Acta Otolaryngol,2007,127:1202-1206.
[33]	PARK S M,LEE D J,CHUNG E J,et al.Conversion from selective to comprehensive neck dissection:is it necessary for occult nodal metastasis? 5-year observational study[J].Clin Exp Otorhinolaryngol,2013,6:94-98.
[34]	WIEGAND S,ESTERS J,MULLER H H, et al.Is it necessary to dissect levels Ⅰ and ⅡB in hypopharyngeal cancer[J]?Acta Otolaryngol,2010,130:747-752.
[35]	PARK H S,CHUNG E J,PARK M W, et al.Usefulness of radiologic examinations for diagnosing level Ⅵ lymph node metastasis in patients with laryngohypopharyngeal carcinoma[J].Eur Arch Otorhinolaryngol,2016. 273:3959-3964.
[36]	CHUNG E J,KIM G W,CHO B K,et al. Pattern of lymph node metastasis in hypopharyngeal squamous cell carcinoma and indications for level Ⅵ lymph node dissection[J]. Head Neck,2016,38:1969-1973.
[37]	PIAZZA C,TAGLIETTI V,NICOLAI P.Reconstructive options after total laryngectomy with subtotal or circumferential hypopharyngectomy and cervical esophagectomy[J]. Head Neck Oncol, 2012,20:77-88.
[38]	CHEN F, LIU J, WANG L H,et al. Free posterior tibial flap reconstruction for Hypopharyngeal squamous cell carcinoma[J].World J Surg Oncol,2014,12:163-164.
[39]	ZHANG C Y, CHEN S C, ZHU M H,et al. Combined use of gastric pull-up and pectoralis major flaps for massive defects after total laryngopharyngoesophagectomy in patients with advanced hypopharyngeal carcinoma[J]. Eur Arch Otorhinolaryngol,2015,272:3557-3564.
[40]	WANG C Y,WANG Q,WANG Z,et al. Lateral tarsal artery flap:an option for hypopharyngeal reconstruction in patients with hypopharyngeal carcinomas after surgery[J]. Int J Clin Exp Med,2015,8:4855-4861.
[41]	STEINER W,AMBROSCH P,HESS C F.Organ presmwation by transoral laser microsurgery in piriform sinus carcinoma[J].Otolaryngol Head Neck Surg,2001,124:58-67.
[42]	黄志刚,倪鑫,房居高,等.经口CO₂激光手术治疗下咽癌[J].中华耳鼻咽喉头颈外科杂志,2009,44(9):722-725.