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摘要: 目的: 系统性评价益生菌对变应性鼻炎的疗效。方法: 系统检索PubMed、The Cochrane Library、Web of SCIence和万方、中国知网、中国生物医学、维普数据库,检索以益生菌为干预措施治疗变应性鼻炎的随机对照试验,检索时限均从建库截至2016年4月。由2名研究者按照纳入与排除标准独立筛选文献、提取资料并评价质量,采用RevMan 5.2软件进行Meta分析。结果: 最终纳入17个随机对照实验,共1 374例患者,其中益生菌组809例,安慰剂组568例。Meta 分析结果显示:益生菌组的总体、鼻部和眼部RQLQ评分、血清嗜酸粒细胞计数均较安慰剂组降低,差异有统计学意义(MD=-4.43,CI为-8.65~-0.20;MD=-1.08,CI为-1.89~0.27;MD=-0.95,CI为-1.46~-1.44;MD=-28.40,CI为-43.53~-13.26);益生菌组的血清IgE水平与安慰剂组差异无统计学意义;乳酸菌组与双歧杆菌组治疗后NTSS值差异无统计学意义(P>0.05)。结论: 与安慰剂组相比较,益生菌组对变应性鼻炎患者的症状改善明显,且不同菌属的益生菌治疗变应性鼻炎疗效差异无统计学意义。Abstract: Objective: To systemically review the therapeutic effect of probitics on allergic rhinitis(AR).Method: Literatures about the effect of probitics on AR were searched in PubMed. The Cochrane Library, Web of Science and CNKI, WanFang Data and VIP inception to April 2016,and 2 reviewers independently screened literatures according to the inclusion and exclusion criteria, extracted data, and assessed the risk of bias of included studies. Then meta-analysis was performed using RevMan5.2 software.Result: A total of 16RCTs involving1374 patients were included in the meta-analysis, including 809 cases in the probitic group and 568 cases in the placebo group. The results of meta-analysis showed that the efficacy of probitic group was superior to the placebo group in total RQLQ,nasal RQLQ,eye RQLQ and the serum eosinophil count,the difference was statistically significant[MD=-4.43,95%CI(-8.65~-0.20);MD=-1.08,95%CI(-1.89~0.27);MD=-0.95,95%CI(-1.46~-1.44);MD=-28.40,95%CI(-43.53~-13.26)].There was no significant difference in Serum IgE between the probitic group and the placebo group(P>0.05).There was no significant difference in the NTSS value between the lactobacillus group and the bifidobacterium group(P>0.05).Conclusion: Compared to the placebo, probitics can effectively reduce symptom scores of patients with AR;and different strains of probitics indicated no significant differences in improving nasal symptoms.
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Key words:
- probitic /
- allergic rhinitis /
- treatment /
- Meta-analysis /
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