Abstract: Objective: To observe the effect of intravenous injection of chlorine on postoperative analgesia and blood oxygen saturation in patients with nasal endoscopic surgery.Method: According to the standard of American Society of anesthesiologists(ASA) grading assessment for Ⅰ-Ⅱ, undergoing nasal endoscopic surgery of 120 patients were randomly divided into two groups, 60 cases in each group. Control group dezocine 0.8 g/kg+ physiological saline to 100 ml; on the basis of the experimental group with flurbiprofen 2 mg/kg+ physiological saline to 100 ml. Respectively in the postoperative recovery and postoperative 2, 4, 12, 24 and 48 h recording vital signs, pain scores(visual analogue score, VAS) and sedation score(Ramsay score) and observe the adverse reaction rate and patient surveys on the satisfaction of postoperative analgesia.Results: The two groups compared test of TKA group after 4, 8, 12, 24, 36 h, 48 h, 72 h resting VAS score and postoperative 24 h, 48 h, 72 h activities of VAS score were lower than the control group, the difference is statistically significant (F=1 873.26,P<0.05). After 2 h, 6 h, 2 groups of pH, PaO₂, PaCO₂, SpO₂ compared statistically significant(P>0.05). After 24h, 48h after test group, PaO₂, PaCO₂, SpO₂ is better than that of the control group(P<0.05); after 6 h, 24 h, 48 h after the test group patients Ramsay Sedation score than the control group, the difference is statistically significant(F=1 031.35,P<0.05). The experimental group after TKA patients of pain control education satisfaction and to control or reduce pain method of satisfaction were superior to the control group, the difference significant(χ²=11.02, P<0.05;χ²=9.33, P<0.05).Conclusion: The application of intravenous injection of intravenous injection of chlorine in the postoperative pain of nasal endoscopic surgery can significantly improve the analgesic effect, improve the blood gas analysis, improve the analgesic effect, it is worthy of popularization and application.