The study on the effect of ginkgo biloba extract on homocysteine and serum lipids concentration of patients with severe OSAHS
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摘要: 目的:探讨银杏叶提取物对重度OSAHS患者外周血清同型半胱氨酸(Hcy)和血脂浓度的影响。方法:采用多导睡眠监测仪筛选出140例重度OSAHS患者,随机分为治疗组和对照组。2组患者均给予基础治疗,治疗组在基础治疗上给予银杏叶提取物注射液治疗,观察2组患者治疗后血清Hcy及血脂浓度的变化。结果:治疗10 d后2组患者外周血清Hcy、总胆固醇、总甘油三酯浓度较治疗前有所降低(P＜0.05),治疗组上述指标均明显低于对照组(均P＜0.05)。结论:在基础治疗基础上给予静脉滴注银杏叶提取物能进一步降低重度OSAHS患者外周血清Hcy与血脂的浓度。
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关键词:
- 睡眠呼吸暂停低通气综合征 /
- 阻塞性 /
- 同型半胱氨酸 /
- 血脂 /
- 银杏叶提取物
Abstract: Objective: To investigate the effects of ginkgo biloba extract on plasma homocysteine and blood lipid concentration of patients with severe OSAHS.Method: One hundred and forty cases of severe OSAHS patients were selected with means of multichannel sleep monitor, and were randomly divided into treatment group and control group.Both the two groups of patients were given basic treatment.In addition, the treatment group was given ginkgo biloba extract injection. The changes of Hcy and lipid concentrations of the two groups of patients after treatment were tested.Result: After 10 days of treatment, peripheral serum Hcy, total cholesterol (total cholesterol, TC), total triglyceride(total triglycerides, TG concentration) in both two groups decreased compared with those before treatment(P<0.05),and above parameters in the treatment group was significantly lower than that in the control group.Conclusion: Intravenous infusion of ginkgo biloba extract can further reduce the serum Hcy and serum lipid concentration in patients with OSAHS.-
Key words:
- sleep apnea hypopnea syndrome /
- obstructive /
- homocysteine /
- blood lipid /
- ginkgo biloba extract
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[1] 中华医学会呼吸病学分会睡眠呼吸疾病学组. 阻塞性睡眠呼吸暂停低通气综合征诊治指南(草案)[J]. 中华结核和呼吸杂志, 2002, 25(4):195-198.
[2] LIPPI G, MATTIUZZI C, FRANCHINI M.Sleep apnea and venous thromboembolism. A systematic review[J].Thromb Haemost,2015114:324-348.
[3] NADEEM R, SINGH M, NIDA M. Effect of obstructive sleep apnea hypopnea ayndrome on lipid profile:a Meta-Regression analysis[J]. J Clin Sleep Med, 2014,10:475-489.
[4] LI L, ZHAN X, WANG N, et al. Does airway surgery lower serum lipid levels in obstructive sleep apnea patients? a retrospective case review[J].Med Sci Monit,2014,20:2651-2657.
[5] NIU X, CHEN X, XIAOY, et al. The differences in homocysteine level between obstructive sleep apnea patients and controls:a meta-nalysiS[J].PLoS One, 2014, 9:e95794-e95794.
[6] WE T I, XIONG F F, WANG S D, et al. Flavonoid ingredients of Ginkgo biloba leaf extract regulate lipid metabolism through Sp1-mediated carnitine Palmitoyltranferase 1A up-regulation[J]:Biomed Sci,2014, 21:87-89.
[7] LIU C J, LAI X Y, CHEN Y L, et al. Ginkgolide c suppresses adipogenesis in 3T3-L1 adipocytes via the AMPK signaling pathway[J]. Evid Based Complement Alternat Med,2015,12:1-10.
[8] JACOB J, JOSEPH L. Methoxistasis:integrating the roles of homocysteine and folic acid in cardiovascular pathobiology[J]. Nutrients, 2013, 5:3235-3256.
[9] KEVIN L S, ANNE L S. Homocysteine imbalance:a pathological metabolic marker[J]. Adv Nutr, 2012, 3:755-762.
[10] SONG S,KERTOWIDJOJO E, OJAIMI C, et al. Longterm methionine-diet induced mild heperhomocysteinemia associated cardiac metabolic dysfunction in multiarous rats[J]. Physiol Rep, 2015, 3:e12292-e12292.
[11] JIA S J, LAI Y Q, ZHAO M, et al. Homocysteine-induced hypermethylation of DDAH2 promoter contributes to apoptosis of endothelial cells[J]. Pharmazie, 2013, 68:282-286.
[12] 顼志兵, 汪卫东, 张莉芬, 等. 银杏叶胶囊对高同型半胱氨酸血症血管内皮细胞凋亡干预的实验研究[J]. 中国中西医结合杂志, 2015, 35(9):1099-1104.
[13] 梁燕玲, 许治强, 匡永锋, 等. 银杏叶提取物对同型半胱氨酸诱导LOX-1mRNA表达升高的拮抗作用[J]. 广东医学, 2008, 29(1):53-55.
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