乙酰肝素酶及NF-E2相关因子对吸烟相关喉鳞状细胞癌的影响

卜川; 魏日富; 朱忠寿; 李海燕; 刘亚超

doi:10.13201/j.issn.1001-1781.2016.15.004

乙酰肝素酶及NF-E2相关因子对吸烟相关喉鳞状细胞癌的影响

- 1 宁德市医院耳鼻喉外科(福建宁德, 352100);
- 2 河北北方学院附属第一医院耳鼻咽喉头颈外科

详细信息

通讯作者: 卜川,E-mail:bochuan4321@qq.com

中图分类号: R739.65

收稿日期: 2016-04-21

Effects of HPA and NF-E2 related factor on smoking related laryngeal squamous cell carcinoma

- 1 Department of ENT Surgery, Ningde Hospital, Ningde, 352100, China;
- 2 Department of Otolaryngology Head and Neck Surgery, the First Affiliated Hospital of Hebei North University

More Information

Corresponding author: BO Chuan, E-mail: bochuan4321@qq.com

Received Date: 21 April 2016

摘要

摘要: 目的: 通过对吸烟相关喉鳞状细胞癌患者乙酰肝素酶(HPA)及NF-E2相关因子(NRF2)的表达情况的分析,进一步探讨二者对吸烟相关喉鳞状细胞癌的预后影响。方法: 连续性收集2014-2015年84例喉鳞状细胞癌患者的临床资料,根据吸烟指数分为3组:重度吸烟组30例、轻中度吸烟组20例及无吸烟组34例。分别检测3组患者血清抗氧化指标及喉癌组织HPA和NRF2的表达水平,结合患者临床资料探讨其与患者预后及临床分期之间的关系。结果: ①Ⅲ~Ⅳ期喉鳞状细胞癌患者癌组织中HPA及NRF2均呈高表达;Ⅰ~Ⅱ期喉鳞状细胞癌患者癌组织中HPA及NRF2均呈低表达。②重度吸烟组NRF2表达水平显著高于轻中度吸烟组和无吸烟组(均P<0.05),且在分期较高的喉鳞状细胞癌患者中其NRF2表达水平均高于分期较低者;③HPA及NRF2的表达与喉鳞状细胞癌患者的临床分期有关(P<0.05)。结论: 与非吸烟患者比较,重度吸烟喉鳞状细胞癌患者面临更加严重的氧化应激压力,喉鳞状细胞癌患者HPA及NRF2的表达水平与其临床病理分期有关,HPA及NRF2高表达可能促使喉鳞状细胞癌患者临床分期升级。
- 喉肿瘤 /
- 乙酰肝素酶 /
- NF-E2相关因子
Abstract: Objective: To further explore the prognostic effects of Heparanase(HPA) and NF-E2 related factor (NRF2) on smoking related laryngeal squamous cell carcinoma, we detect the expression of HPA and NRF2 on smoking related laryngeal squamous cell carcinoma patients.Method: Continuously collected 84 patients with laryngeal squamous cell carcinoma in the Ningde Hospital from 2014 to 2015. All patients were divided into three groups according to smoking index:group A (severe smoking patients with laryngeal carcinoma 30 cases), group B(mild to moderate smokers 20 cases) and group C (no smoking in laryngeal carcinoma patients with 34 cases). Antioxidative indices in serum and the expression of HPA and NRF2 in three groups of patients were detected, and to explore their relationship with prognosis and clinical staging of patients.Result: The HPA and NRF2 were highly expressed in the cancer tissues of patients with stage Ⅲ-Ⅳ, while the expression of HPA and NRF2 in patients with stage Ⅰ-Ⅱ was low. The expression level of NRF2 in group A was significantly higher than that of group Band group C(P<0.05) as well as the NRF2 expression levels in higher stage patients with laryngeal cancer were higher than those of low stages. The expression of HPA and NRF2 is related to the pathological stage in laryngeal squamous cell carcinoma patients(P<0.05).Conclusion: Compared with non smoking patients, severe smoking patients with laryngeal cancer will face more severe oxidative stress. The expression of HPA and NRF2 in laryngeal squamous cell carcinoma patients is related to the pathological stage.
- laryngeal neoplasms /
- heparanase /
- NRF2

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