幼年型复发性呼吸道乳头状瘤病HPV型别测定和临床分析

杨蓦雷; 王军; 肖洋

doi:10.13201/j.issn.1001-1781.2016.09.015

幼年型复发性呼吸道乳头状瘤病HPV型别测定和临床分析

- 首都医科大学附属北京同仁医院耳鼻咽喉头颈外科(北京, 100730)
基金项目:
国家自然科学基金资助项目（No：81170900）

详细信息

通讯作者: 王军,E-mail:wmzi2002@163.com

中图分类号: R739.6

收稿日期: 2016-01-16

HPV type determination and clinical characteristics in juvenile onset recurrent respiratory papillomatosis

- Department of Otolaryngology-Head and Neck Surgery, Tongren Hospital, Capital Medical University, Beijing, 100730, China

More Information

Corresponding author: WANG Jun, E-mail: wmzi2002@163.com

Received Date: 16 January 2016

摘要

摘要: 目的：探讨人乳头瘤病毒（HPV）感染型别与幼年型复发性呼吸道乳头状瘤病（JORRP）患儿临床特征之间的联系。方法：回顾性分析2010-2014年就诊的240例JORRP患儿，取手术时留取的肿瘤标本进行HPV型别测定，分析感染不同HPV亚型患儿临床表现的差异。结果：JORRP患儿病毒感染型别除单纯HPV11型感染或HPV6型感染外，存在部分HPV11和HPV6型混合感染；感染HPV11型的患儿较感染HPV6型患儿发病年龄小、手术次数多、术中Derkay评分更高，经检验结果差异有统计学意义（P<0.05）。结论：从发病年龄、手术次数及肿瘤生长方式角度考量，感染HPV11型的患儿病情较感染HPV6型的患儿更为严重。
- 人乳头状瘤病毒 /
- 呼吸道肿瘤 /
- 儿童
Abstract: Objective: To investigate the relationship between different subtypes of human papillomavirus(HPV) infection and clinical features in juvenile onset recurrent respiratory papillomatosis(JORRP) patients.Method: Two hundred and forty cases with JORRP from 2010 to 2014 were retrospectively analyzed. HPV tpye were determined using tumor specimens taken from surgery, and all patients were divided into different groups based on HPV type. Clinical characteristics of patients from each groups were analyzed.Result: Except for HPV11 single infection or HPV6 single infection, some HPV11 and 6 co-infections were found in children with JORRP. Compared with patients with HPV6 single infection, HPV11 positive patients present an earlier age of onset, more times of operation and higher derkay score during surgery.Conclusion: JORRP in patients infected with HPV11 is more severe than that in patients with HPV6 infection in children.
- human papillomavirus /
- respiratory tract neoplasms /
- children

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参考文献(10)

[1]	DERKAY C S,HESTER R P,BURKE B,et al.Analysis of a staging assessment system for prediction of surgical interval in recurrent respiratory papillomatosis[J].Int J Pediatr Otorhinolaryngol,2004,68:1493-1498.
[2]	SANCHEZ G I,JARAMILLO R,CUELLO G,et al.Human papillomavirus genotype detection in recurrent respiratory papillomatosis(RRP)in Colombia[J].Head Neck,2013,35:229-234.
[3]	SILVERBERG M J,THORSEN P,LINDEBERG H,et al.Condyloma in pregnancy is strongly predictive of juvenile onset recurrent respiratory papillomatosis[J].Obstetrics Gynecol,2003,101:645-652.
[4]	DOYLE D J,GIANOLI G J,ESPINOLA T,et al.Recurrent respiratory papillomatosis:juvenile versus adult forms[J].Laryngoscope,1994,104:523-527.
[5]	BUCHINSKY F J,DONFACK J,DERKAY C S,et al.Age of child,more than HPV type,is associated with clinical course in recurrent respiratory papillomatosis[J].PLoS One,2008,3:e2263-e2263.
[6]	DRAGANOV P,TODOROV S,TODOROV I,et al.Identification of HPV DNA in patients with juvenileonset recurrent respiratory papillomatosis using SYBR?Green real-time PCR[J].Int J Pediatr Otorhinolaryngol,2006,70:469-473.
[7]	DONNE A J,HAMPSON L,HOMER J J.Hampson iN(2010)the role of HPV type in recurrent respiratory papillomatosis[J].Int J Pediatr Otorhinolaryngol,2010,74:7-14.
[8]	MALONEY E M,UNGER E R,TUCKER R A,et al.Longitudinal measures of human papillomavirus 6and 11viral loads and antibody response in children with recurrent respiratory papillomatosis[J].Arch Otolaryngol Head Neck Surg,2006,132:711-715.
[9]	WIATRAK B J,WIATRAK D W,BROKER T R,et al.Recurrent respiratory papillomatosis:a longitudinal study comparing severity associated with human papilloma viral types 6and 11and other risk factors in a large pediatric population[J].Laryngoscope,2004,114:1-23.
[10]	OMLAND T,AKRE H,LIE K A,et al.Risk factors for aggressive recurrent respiratory papillomatosis in adults and juveniles[J].PLoS One,2014,9:e113584-e113584.